

| Benched | RB | Blake Corum LAR | Owner | Fri Dec 12 10:49am ET |
| Benched | TE | Brenton Strange JAX | Owner | Fri Dec 12 10:49am ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Fri Dec 12 10:49am ET |
| Started | TE | Isaiah Likely BAL | Owner | Fri Dec 12 10:49am ET |
| Benched | WR | Keon Coleman BUF | Owner | Tue Dec 9 2:30pm ET |
| Started | RB | Blake Corum LAR | Owner | Tue Dec 9 2:30pm ET |
| Benched | RB | Chris Rodriguez Jr. WAS | Owner | Tue Dec 9 9:34am ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Dec 9 9:34am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Breece Hall NYJ | Owner | Tue Dec 9 1:21pm ET |
| Benched | WR | Ladd McConkey LAC | Owner | Tue Dec 9 1:21pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Dec 9 1:21pm ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Dec 9 1:21pm ET |
| Benched | QB | Bo Nix DEN | Owner | Tue Dec 9 1:20pm ET |
| Started | QB | Drake Maye NE | Owner | Tue Dec 9 1:20pm ET |
| Started | WR | D.J. Moore CHI | Owner | Fri Dec 12 1:28pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Fri Dec 12 1:28pm ET |
| Started | K | Cam Little JAX | Owner | Wed Dec 10 4:28pm ET |
| Benched | K | Wil Lutz DEN | Owner | Wed Dec 10 4:28pm ET |
| Started | WR | Tee Higgins CIN | Owner | Wed Dec 10 4:23pm ET |
| Benched | RB | Ashton Jeanty LV | Owner | Wed Dec 10 4:23pm ET |
| Started | D/ST | Kansas City Chiefs KC | Owner | Tue Dec 9 9:24am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Dec 9 9:24am ET |
| Started | RB | Chuba Hubbard CAR | Owner | Tue Dec 9 9:24am ET |
| Started | RB | Rico Dowdle CAR | Owner | Tue Dec 9 9:24am ET |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Tue Dec 9 9:24am ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Dec 9 9:24am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Dec 9 9:24am ET |
| Benched | RB | Jordan Mason MIN | Owner | Tue Dec 9 9:24am ET |
| Benched | WR | John Metchie III NYJ | Owner | Tue Dec 9 6:52pm ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Dec 9 6:52pm ET |
| Benched | QB | Kirk Cousins ATL | Owner | Tue Dec 9 3:32pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Dec 9 3:32pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Dec 9 3:32pm ET |
| Started | QB | Bryce Young CAR | Owner | Tue Dec 9 3:32pm ET |
| Started | RB | Christian McCaffrey SF | Owner | Tue Dec 9 3:32pm ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Dec 9 3:32pm ET |
| Benched | D/ST | Tennessee Titans TEN | Owner | Thu Dec 11 7:26am ET |
| Started | D/ST | Chicago Bears CHI | Owner | Thu Dec 11 7:26am ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Dec 9 8:28am ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Dec 9 8:28am ET |
| Benched | RB | David Montgomery DET | Owner | Wed Dec 10 2:04pm ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Wed Dec 10 2:04pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Wed Dec 10 2:04pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Dec 10 2:04pm ET |
| Benched | QB | Jared Goff DET | Owner | Tue Dec 9 1:45pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Dec 9 1:45pm ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Dec 9 1:45pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Dec 9 1:45pm ET |
| Benched | TE | Zach Ertz WAS | Owner | Tue Dec 9 1:44pm ET |
| Started | TE | George Kittle SF | Owner | Tue Dec 9 1:44pm ET |
| Benched | QB | Sam Darnold SEA | Owner | Wed Dec 10 11:51am ET |
| Started | QB | Brock Purdy SF | Owner | Wed Dec 10 11:51am ET |
| Benched | TE | Mason Taylor NYJ | Owner | Thu Dec 11 4:31pm ET |
| Started | WR | Jalen Coker CAR | Owner | Thu Dec 11 4:31pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Alec Pierce IND | Owner | Tue Dec 9 6:03pm ET |
| Started | WR | Jerry Jeudy CLE | Owner | Tue Dec 9 6:03pm ET |