

| Benched | RB | Rachaad White TB | Owner | Wed Nov 5 2:12pm ET |
| Started | RB | Christian McCaffrey SF | Owner | Wed Nov 5 2:12pm ET |
| Benched | RB | Ollie Gordon II MIA | Owner | Wed Nov 5 10:04am ET |
| Benched | RB | Brashard Smith KC | Owner | Wed Nov 5 10:04am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Wed Nov 5 10:04am ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 5 10:04am ET |
| Started | RB | Rachaad White TB | Owner | Wed Nov 5 10:04am ET |
| Started | WR | Stefon Diggs NE | Owner | Wed Nov 5 10:04am ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 5:22pm ET |
| Started | TE | Jake Tonges SF | Owner | Tue Nov 4 5:22pm ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 2:02pm ET |
| Benched | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 4 2:02pm ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 4 2:02pm ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 4 2:02pm ET |
| Benched | K | Harrison Butker KC | Owner | Wed Nov 5 11:11am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 4 9:45pm ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Tue Nov 4 9:45pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 4 9:45pm ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 9:45pm ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 9:45pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 9:45pm ET |
| No starting lineup changes performed this week. |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 6:59pm ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 4 6:59pm ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 6:59pm ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 4 6:59pm ET |
| Started | RB | Zach Charbonnet SEA | Owner | Tue Nov 4 6:59pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 4 6:59pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 6:59pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 6:59pm ET |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 6:59pm ET |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 4 6:59pm ET |
| Benched | QB | Dak Prescott DAL | Owner | Wed Nov 5 5:37am ET |
| Benched | RB | Javonte Williams DAL | Owner | Wed Nov 5 5:37am ET |
| Benched | WR | George Pickens DAL | Owner | Wed Nov 5 5:37am ET |
| Started | RB | Jaylen Warren PIT | Owner | Wed Nov 5 5:37am ET |
| Started | WR | Jordan Addison MIN | Owner | Wed Nov 5 5:37am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 4 10:31pm ET |
| Started | WR | Zay Flowers BAL | Owner | Tue Nov 4 10:31pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 8:32am ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 8:32am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 4 5:42pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 5:42pm ET |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 4 7:54am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 4 7:54am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 7:54am ET |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 7:54am ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 4 7:54am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 4 7:54am ET |
| Benched | WR | Rashee Rice KC | Owner | Wed Nov 5 9:40am ET |
| Started | WR | Tez Johnson TB | Owner | Wed Nov 5 9:40am ET |