

| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 1:15pm ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 1:15pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 1:15pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 1:15pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Fri Nov 28 6:32pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Fri Nov 28 6:32pm ET |
| Benched | TE | Luke Musgrave GB | Owner | Wed Nov 26 10:59am ET |
| Started | WR | Chimere Dike TEN | Owner | Wed Nov 26 10:59am ET |
| Benched | RB | Raheem Mostert LV | Owner | Tue Nov 25 6:07pm ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 6:07pm ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Nov 25 6:07pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:07pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 6:07pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 6:07pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Tyjae Spears TEN | Owner | Wed Nov 26 4:11pm ET |
| Benched | K | Harrison Butker KC | Owner | Wed Nov 26 4:11pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 4:11pm ET |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 4:11pm ET |
| Benched | QB | Lamar Jackson BAL | Owner | Wed Nov 26 11:02am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 11:02am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Wed Nov 26 11:02am ET |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 11:02am ET |
| Started | QB | Matthew Stafford LAR | Owner | Wed Nov 26 11:02am ET |
| Started | RB | Aaron Jones MIN | Owner | Wed Nov 26 11:02am ET |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 11:02am ET |
| Started | D/ST | Kansas City Chiefs KC | Owner | Wed Nov 26 11:02am ET |
| Benched | QB | Sam Darnold SEA | Owner | Fri Nov 28 5:52pm ET |
| Started | QB | Daniel Jones IND | Owner | Fri Nov 28 5:52pm ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Fri Nov 28 2:57pm ET |
| Started | WR | A.J. Brown PHI | Owner | Fri Nov 28 2:57pm ET |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 7:46pm ET |
| Started | QB | Sam Darnold SEA | Owner | Wed Nov 26 7:46pm ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Wed Nov 26 8:08pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 8:08pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 6:01pm ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 6:01pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 11:50am ET |
| Started | RB | Tyler Allgeier ATL | Owner | Thu Nov 27 11:50am ET |
| Benched | RB | Kyle Juszczyk SF | Owner | Wed Nov 26 3:21pm ET |
| Benched | TE | Jonnu Smith PIT | Owner | Wed Nov 26 3:21pm ET |
| Started | RB | Jeremy McNichols WAS | Owner | Wed Nov 26 3:21pm ET |
| Started | TE | Mike Gesicki CIN | Owner | Wed Nov 26 3:21pm ET |
| Benched | QB | Geno Smith LV | Owner | Wed Nov 26 3:21pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 3:21pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 27 8:19am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Thu Nov 27 8:19am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 8:19am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 8:19am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 8:19am ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 8:19am ET |
| Benched | TE | Cade Otton TB | Owner | Thu Nov 27 8:19am ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 8:19am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Thu Nov 27 8:19am ET |
| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 8:19am ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 9:30am ET |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 25 9:30am ET |