

| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 2:20pm ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Oct 28 2:20pm ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Oct 28 2:20pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Oct 28 2:20pm ET |
| Started | RB | Ollie Gordon II MIA | Owner | Tue Oct 28 2:20pm ET |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 2:20pm ET |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 2:20pm ET |
| Started | TE | Sam LaPorta DET | Owner | Tue Oct 28 2:20pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Zavier Scott MIN | Owner | Tue Oct 28 10:23am ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Oct 28 10:23am ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Oct 28 10:23am ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 10:23am ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 10:23am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Oct 28 10:23am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 7:03pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Oct 28 7:03pm ET |
| Started | WR | Drake London ATL | Owner | Tue Oct 28 7:03pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Oct 28 7:03pm ET |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Oct 28 7:03pm ET |
| Benched | TE | Dalton Kincaid BUF | Owner | Tue Oct 28 7:03pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 7:03pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 7:03pm ET |
| Benched | RB | Breece Hall NYJ | Owner | Tue Oct 28 7:03pm ET |
| Started | TE | Trey McBride ARI | Owner | Tue Oct 28 7:03pm ET |
| No starting lineup changes performed this week. |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Oct 28 6:54pm ET |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 6:54pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Justin Fields NYJ | Owner | Tue Oct 28 2:53pm ET |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 2:53pm ET |
| Benched | RB | Cam Skattebo NYG | Owner | Tue Oct 28 4:51pm ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Oct 28 4:51pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 4:51pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Oct 28 4:51pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Oct 28 8:45am ET |
| Benched | WR | Tez Johnson TB | Owner | Tue Oct 28 8:45am ET |
| Benched | K | Chase McLaughlin TB | Owner | Tue Oct 28 8:45am ET |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Oct 28 8:45am ET |
| Started | QB | Jared Goff DET | Owner | Tue Oct 28 8:45am ET |
| Started | WR | Cooper Kupp SEA | Owner | Tue Oct 28 8:45am ET |