

| Benched | RB | Rachaad White TB | Owner | Wed Nov 19 10:08am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Wed Nov 19 10:08am ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 19 10:08am ET |
| Started | WR | Stefon Diggs NE | Owner | Wed Nov 19 10:08am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Marcus Mariota WAS | Owner | Tue Nov 18 2:23pm ET |
| Started | K | Will Reichard MIN | Owner | Tue Nov 18 2:23pm ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 18 2:23pm ET |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 18 2:23pm ET |
| Started | QB | Patrick Mahomes KC | Owner | Tue Nov 18 2:23pm ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 18 2:23pm ET |
| Benched | K | Matt Prater BUF | Owner | Tue Nov 18 2:23pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 18 2:23pm ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Nov 18 2:23pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 18 2:23pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Drake London ATL | Owner | Tue Nov 18 6:35pm ET |
| Benched | WR | Ladd McConkey LAC | Owner | Tue Nov 18 6:35pm ET |
| Benched | K | Cameron Dicker LAC | Owner | Tue Nov 18 6:35pm ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 18 6:35pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 18 6:35pm ET |
| Started | K | Harrison Butker KC | Owner | Tue Nov 18 6:35pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 19 4:08pm ET |
| Benched | WR | A.J. Brown PHI | Owner | Wed Nov 19 4:08pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 19 4:08pm ET |
| Started | RB | Jonathan Taylor IND | Owner | Wed Nov 19 4:08pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 18 8:56pm ET |
| Started | RB | Woody Marks HOU | Owner | Tue Nov 18 8:56pm ET |
| Benched | WR | Keenan Allen LAC | Owner | Tue Nov 18 9:53am ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Tue Nov 18 9:53am ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 18 9:53am ET |
| Benched | QB | Justin Herbert LAC | Owner | Wed Nov 19 4:01pm ET |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Nov 19 4:01pm ET |
| Started | QB | Caleb Williams CHI | Owner | Wed Nov 19 4:01pm ET |
| Started | RB | Alvin Kamara NO | Owner | Wed Nov 19 4:01pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Devon Achane MIA | Owner | Tue Nov 18 8:00pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 18 8:00pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 18 8:00pm ET |
| Started | TE | David Njoku CLE | Owner | Tue Nov 18 8:00pm ET |
| No starting lineup changes performed this week. |