

| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Nov 25 11:58am CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 25 11:58am CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 8:14pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:14pm CT |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 8:13pm CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 8:13pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 8:13pm CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 8:13pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 3:26pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 3:26pm CT |
| Started | WR | John Metchie III NYJ | Owner | Thu Nov 27 8:40am CT |
| Started | RB | Jaleel McLaughlin DEN | Owner | Thu Nov 27 8:40am CT |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Thu Nov 27 8:40am CT |
| Benched | WR | Tez Johnson TB | Owner | Thu Nov 27 8:40am CT |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 8:40am CT |
| Benched | RB | Brashard Smith KC | Owner | Thu Nov 27 8:40am CT |
| Started | WR | Tez Johnson TB | Owner | Wed Nov 26 6:36pm CT |
| Started | RB | Brashard Smith KC | Owner | Wed Nov 26 6:36pm CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 6:36pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 6:36pm CT |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 6:36pm CT |
| Benched | QB | Jameis Winston NYG | Owner | Wed Nov 26 6:36pm CT |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 6:29am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 6:29am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Wed Nov 26 9:02am CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 9:02am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sat Nov 29 9:23am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 5:35am CT |
| Started | WR | George Pickens DAL | Owner | Thu Nov 27 5:35am CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 25 10:11am CT |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 25 10:11am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 10:11am CT |
| Benched | TE | Cole Kmet CHI | Owner | Thu Nov 27 7:55am CT |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 7:55am CT |
| Benched | TE | Dawson Knox BUF | Owner | Thu Nov 27 7:55am CT |
| Started | TE | Cole Kmet CHI | Owner | Thu Nov 27 7:55am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Thu Nov 27 7:54am CT |
| Started | WR | Terry McLaurin WAS | Owner | Thu Nov 27 7:54am CT |
| Benched | TE | Cole Kmet CHI | Owner | Wed Nov 26 9:36am CT |
| Started | TE | Dawson Knox BUF | Owner | Wed Nov 26 9:36am CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Sat Nov 29 9:21pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Sat Nov 29 9:21pm CT |
| Benched | K | Jake Bates DET | Owner | Tue Nov 25 10:24pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 10:24pm CT |