

| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Nov 25 12:58pm ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 25 12:58pm ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 9:14pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 9:14pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 9:13pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 9:13pm ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 9:13pm ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 9:13pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Sun Nov 30 5:58am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 4:26pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 4:26pm ET |
| Started | WR | John Metchie III NYJ | Owner | Thu Nov 27 9:40am ET |
| Started | RB | Jaleel McLaughlin DEN | Owner | Thu Nov 27 9:40am ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Thu Nov 27 9:40am ET |
| Benched | WR | Tez Johnson TB | Owner | Thu Nov 27 9:40am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 9:40am ET |
| Benched | RB | Brashard Smith KC | Owner | Thu Nov 27 9:40am ET |
| Started | WR | Tez Johnson TB | Owner | Wed Nov 26 7:36pm ET |
| Started | RB | Brashard Smith KC | Owner | Wed Nov 26 7:36pm ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 7:36pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 7:36pm ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 7:36pm ET |
| Benched | QB | Jameis Winston NYG | Owner | Wed Nov 26 7:36pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 7:29am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:29am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Wed Nov 26 10:02am ET |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 10:02am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sat Nov 29 10:23am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 6:35am ET |
| Started | WR | George Pickens DAL | Owner | Thu Nov 27 6:35am ET |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 25 11:11am ET |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 25 11:11am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 11:11am ET |
| Benched | TE | Cole Kmet CHI | Owner | Thu Nov 27 8:55am ET |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 8:55am ET |
| Benched | TE | Dawson Knox BUF | Owner | Thu Nov 27 8:55am ET |
| Started | TE | Cole Kmet CHI | Owner | Thu Nov 27 8:55am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Thu Nov 27 8:54am ET |
| Started | WR | Terry McLaurin WAS | Owner | Thu Nov 27 8:54am ET |
| Benched | TE | Cole Kmet CHI | Owner | Wed Nov 26 10:36am ET |
| Started | TE | Dawson Knox BUF | Owner | Wed Nov 26 10:36am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Sat Nov 29 10:21pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Sat Nov 29 10:21pm ET |
| Benched | K | Jake Bates DET | Owner | Tue Nov 25 11:24pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 11:24pm ET |