

| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 7:43am ET |
| Started | RB | Kyle Monangai CHI | Owner | Thu Nov 27 7:43am ET |
| Started | QB | Geno Smith LV | Owner | Sun Nov 30 7:13am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Sun Nov 30 7:13am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 12:51pm ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Thu Nov 27 12:51pm ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 12:51pm ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 12:51pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Thu Nov 27 12:51pm ET |
| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 12:51pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 12:51pm ET |
| Benched | QB | Davis Mills HOU | Owner | Thu Nov 27 12:51pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 12:49pm ET |
| Benched | QB | Cam Ward TEN | Owner | Thu Nov 27 12:49pm ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Thu Nov 27 12:49pm ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 12:49pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Thu Nov 27 12:49pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 12:49pm ET |
| Benched | QB | Tyler Shough NO | Owner | Fri Nov 28 7:45am ET |
| Benched | WR | D.J. Moore CHI | Owner | Fri Nov 28 7:45am ET |
| Started | QB | Justin Herbert LAC | Owner | Fri Nov 28 7:45am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Fri Nov 28 7:45am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Tank Bigsby PHI | Owner | Thu Nov 27 1:45pm ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 1:45pm ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Thu Nov 27 1:45pm ET |
| Started | K | Tyler Loop BAL | Owner | Thu Nov 27 1:44pm ET |
| Benched | RB | Bucky Irving TB | Owner | Thu Nov 27 1:42pm ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 1:42pm ET |
| Benched | WR | Cooper Kupp SEA | Owner | Fri Nov 28 4:19pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Fri Nov 28 4:19pm ET |
| Benched | QB | Jameis Winston NYG | Owner | Fri Nov 28 4:18pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Fri Nov 28 4:18pm ET |
| Benched | QB | Daniel Jones IND | Owner | Sun Nov 30 9:14am ET |
| Started | QB | C.J. Stroud HOU | Owner | Sun Nov 30 9:14am ET |
| Benched | RB | Bucky Irving TB | Owner | Sun Nov 30 9:13am ET |
| Started | WR | Troy Franklin DEN | Owner | Sun Nov 30 9:13am ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 27 8:43am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 8:43am ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 5:28pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 5:28pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 7:01am ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 7:01am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 7:01am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 7:01am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Sun Nov 30 9:05am ET |
| Benched | WR | Jauan Jennings SF | Owner | Sun Nov 30 9:05am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Sun Nov 30 9:05am ET |
| Started | WR | Terry McLaurin WAS | Owner | Sun Nov 30 9:05am ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 10:49am ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 10:49am ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 10:11am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 10:11am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 10:11am ET |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 10:11am ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Thu Nov 27 12:50pm ET |
| Started | WR | Michael Wilson ARI | Owner | Thu Nov 27 12:50pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 12:45pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 27 12:42pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 12:42pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 12:42pm ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 12:42pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 12:42pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 12:42pm ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Thu Nov 27 12:55pm ET |
| Started | WR | Zay Flowers BAL | Owner | Thu Nov 27 12:55pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 7:27pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:27pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:27pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 7:27pm ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 7:08am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 7:08am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 25 2:25pm ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 2:25pm ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Thu Nov 27 12:24pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 12:24pm ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Thu Nov 27 12:24pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 12:24pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 11:44am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 11:44am ET |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 27 12:39pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Thu Nov 27 12:39pm ET |
| Benched | WR | Jameson Williams DET | Owner | Thu Nov 27 11:13am ET |
| Started | WR | Michael Wilson ARI | Owner | Thu Nov 27 11:13am ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 27 10:43am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 10:43am ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 7:30pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 7:30pm ET |
| No starting lineup changes performed this week. |
| Started | D/ST | San Francisco 49ers SF | Owner | Thu Nov 27 12:56pm ET |
| Benched | WR | Christian Watson GB | Owner | Wed Nov 26 1:02am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 1:02am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 9:31am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Thu Nov 27 9:31am ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Thu Nov 27 9:21am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 9:21am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 7:52pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 7:52pm ET |
| Started | TE | Jake Ferguson DAL | Owner | Wed Nov 26 7:47pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Wed Nov 26 7:47pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 5:52pm ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 5:52pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 5:31pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 5:31pm ET |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 1:30pm ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 1:30pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 1:30pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 1:30pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Thu Nov 27 10:45am ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 10:45am ET |
| Started | RB | Javonte Williams DAL | Owner | Tue Nov 25 1:21pm ET |
| Benched | RB | Omarion Hampton LAC | Owner | Tue Nov 25 1:21pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 1:20pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 1:20pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 1:20pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Nov 25 1:20pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:20pm ET |
| Benched | K | Nick Folk NYJ | Owner | Tue Nov 25 1:20pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 1:20pm ET |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 1:20pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 25 1:20pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 1:20pm ET |
| Benched | WR | Tetairoa McMillan CAR | Owner | Wed Nov 26 2:25pm ET |
| Started | WR | Rashee Rice KC | Owner | Wed Nov 26 2:25pm ET |
| Benched | WR | Rashee Rice KC | Owner | Wed Nov 26 2:24pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 2:24pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 2:24pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 2:24pm ET |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Wed Nov 26 2:21pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 2:21pm ET |
| Benched | RB | Kenneth Gainwell PIT | Commissioner | Thu Nov 27 9:49am ET |
| Started | WR | Courtland Sutton DEN | Commissioner | Thu Nov 27 9:49am ET |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 8:07pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:07pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 11:37am ET |
| Started | WR | Khalil Shakir BUF | Owner | Thu Nov 27 11:37am ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 12:03pm ET |
| Benched | WR | Stefon Diggs NE | Owner | Thu Nov 27 12:03pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 12:03pm ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 12:03pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 12:03pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Nov 27 5:28pm ET |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 6:42pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 6:42pm ET |
| Benched | D/ST | Green Bay Packers GB | Owner | Tue Nov 25 2:11pm ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 2:11pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 7:36pm ET |
| Benched | WR | Rome Odunze CHI | Owner | Tue Nov 25 7:36pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 7:36pm ET |
| Started | TE | Tyler Warren IND | Owner | Tue Nov 25 7:36pm ET |
| Benched | RB | Woody Marks HOU | Owner | Sat Nov 29 11:28am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 11:28am ET |
| Started | D/ST | Houston Texans HOU | Owner | Thu Nov 27 7:11am ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Wed Nov 26 9:51pm ET |
| Started | RB | Woody Marks HOU | Owner | Wed Nov 26 9:51pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Thu Nov 27 10:57am ET |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 27 10:57am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 10:57am ET |
| Started | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 10:57am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 10:57am ET |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 27 10:57am ET |
| Benched | RB | Woody Marks HOU | Owner | Thu Nov 27 10:57am ET |
| Started | RB | Jaylen Warren PIT | Owner | Thu Nov 27 10:57am ET |
| Benched | QB | Bryce Young CAR | Owner | Wed Nov 26 8:11am ET |
| Started | QB | Tyrod Taylor NYJ | Owner | Wed Nov 26 8:11am ET |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 8:10am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 8:10am ET |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 5:59pm ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 5:59pm ET |
| Benched | RB | Devin Singletary NYG | Owner | Wed Nov 26 1:09pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 1:09pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 1:08pm ET |
| Started | TE | Dallas Goedert PHI | Owner | Wed Nov 26 1:08pm ET |
| Benched | D/ST | Detroit Lions DET | Owner | Thu Nov 27 12:16pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Nov 27 12:16pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 12:16pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 12:16pm ET |
| Benched | QB | Davis Mills HOU | Owner | Thu Nov 27 12:13pm ET |
| Started | QB | Cam Ward TEN | Owner | Thu Nov 27 12:13pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 3:13pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 3:13pm ET |
| Benched | RB | Kenneth Walker III SEA | Owner | Thu Nov 27 9:08am ET |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 9:08am ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 1:21pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 1:21pm ET |
| Started | K | Tyler Loop BAL | Owner | Thu Nov 27 1:37pm ET |