

| Benched | WR | Darius Slayton NYG | Owner | Thu Nov 27 12:48am ET |
| Started | WR | Romeo Doubs GB | Owner | Thu Nov 27 12:48am ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 8:01pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 8:01pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:01pm ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 8:01pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 8:01pm ET |
| Started | WR | Darius Slayton NYG | Owner | Tue Nov 25 8:01pm ET |
| Benched | RB | Justice Hill BAL | Owner | Thu Nov 27 10:48am ET |
| Started | WR | Elic Ayomanor TEN | Owner | Thu Nov 27 10:48am ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 12:33pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 2:24pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 2:24pm ET |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 8:35am ET |
| Benched | WR | Josh Downs IND | Owner | Thu Nov 27 8:35am ET |
| Started | WR | Josh Downs IND | Owner | Thu Nov 27 8:35am ET |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 8:35am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 8:34am ET |
| Benched | WR | Josh Downs IND | Owner | Thu Nov 27 8:34am ET |
| Started | QB | Daniel Jones IND | Owner | Thu Nov 27 8:34am ET |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 8:34am ET |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 8:31am ET |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 27 8:31am ET |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Nov 25 1:36pm ET |
| Benched | WR | Olamide Zaccheaus CHI | Owner | Tue Nov 25 1:36pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 1:36pm ET |
| Started | WR | Demario Douglas NE | Owner | Tue Nov 25 1:36pm ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 7:44am ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 7:44am ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 26 4:26pm ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 4:26pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 4:26pm ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 4:26pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 1:47am ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 1:47am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 1:47am ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 1:47am ET |
| Benched | TE | George Kittle SF | Owner | Sun Nov 30 8:51am ET |
| Started | TE | Juwan Johnson NO | Owner | Sun Nov 30 8:51am ET |
| Benched | WR | Parker Washington JAX | Owner | Sat Nov 29 9:54am ET |
| Started | WR | Terry McLaurin WAS | Owner | Sat Nov 29 9:54am ET |
| Benched | QB | Bryce Young CAR | Owner | Thu Nov 27 3:52am ET |
| Started | QB | Shedeur Sanders CLE | Owner | Thu Nov 27 3:52am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 6:04am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Nov 26 6:04am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 6:04am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 6:04am ET |
| Benched | TE | Theo Johnson NYG | Owner | Thu Nov 27 11:49am ET |
| Started | TE | Jake Ferguson DAL | Owner | Thu Nov 27 11:49am ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 9:27pm ET |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 25 9:27pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 9:27pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:27pm ET |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 7:12pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:12pm ET |