

| Benched | WR | Darius Slayton NYG | Owner | Wed Nov 26 11:48pm CT |
| Started | WR | Romeo Doubs GB | Owner | Wed Nov 26 11:48pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 7:01pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 7:01pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:01pm CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 7:01pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 7:01pm CT |
| Started | WR | Darius Slayton NYG | Owner | Tue Nov 25 7:01pm CT |
| Benched | RB | Justice Hill BAL | Owner | Thu Nov 27 9:48am CT |
| Started | WR | Elic Ayomanor TEN | Owner | Thu Nov 27 9:48am CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 11:33am CT |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 1:24pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 1:24pm CT |
| Started | WR | Andrei Iosivas CIN | Owner | Thu Nov 27 7:35am CT |
| Benched | WR | Josh Downs IND | Owner | Thu Nov 27 7:35am CT |
| Started | WR | Josh Downs IND | Owner | Thu Nov 27 7:35am CT |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 7:35am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 27 7:34am CT |
| Benched | WR | Josh Downs IND | Owner | Thu Nov 27 7:34am CT |
| Started | QB | Daniel Jones IND | Owner | Thu Nov 27 7:34am CT |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 7:34am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Thu Nov 27 7:31am CT |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 27 7:31am CT |
| Benched | RB | Rico Dowdle CAR | Owner | Tue Nov 25 12:36pm CT |
| Benched | WR | Olamide Zaccheaus CHI | Owner | Tue Nov 25 12:36pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 12:36pm CT |
| Started | WR | Demario Douglas NE | Owner | Tue Nov 25 12:36pm CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 6:44am CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 6:44am CT |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 26 3:26pm CT |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 3:26pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 3:26pm CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 3:26pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 12:47am CT |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 12:47am CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Thu Nov 27 12:47am CT |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 12:47am CT |
| Benched | WR | Parker Washington JAX | Owner | Sat Nov 29 8:54am CT |
| Started | WR | Terry McLaurin WAS | Owner | Sat Nov 29 8:54am CT |
| Benched | QB | Bryce Young CAR | Owner | Thu Nov 27 2:52am CT |
| Started | QB | Shedeur Sanders CLE | Owner | Thu Nov 27 2:52am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 5:04am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Nov 26 5:04am CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 5:04am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 5:04am CT |
| Benched | TE | Theo Johnson NYG | Owner | Thu Nov 27 10:49am CT |
| Started | TE | Jake Ferguson DAL | Owner | Thu Nov 27 10:49am CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 8:27pm CT |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 25 8:27pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:27pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:27pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 6:12pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 6:12pm CT |