

| Benched | RB | Tony Pollard TEN | Owner | Sun Nov 30 12:07pm ET |
| Benched | WR | Tez Johnson TB | Owner | Sun Nov 30 12:07pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Sun Nov 30 12:07pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sun Nov 30 12:07pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 10:07pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 10:07pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:07pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 26 10:07pm ET |
| Started | TE | Darren Waller MIA | Owner | Sun Nov 30 4:58am ET |
| Benched | TE | Dalton Kincaid BUF | Owner | Sun Nov 30 4:58am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 3:44am ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Thu Nov 27 3:44am ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Thu Nov 27 3:42am ET |
| Benched | WR | D.J. Moore CHI | Owner | Thu Nov 27 3:42am ET |
| Started | TE | Dalton Kincaid BUF | Owner | Wed Nov 26 12:18am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 12:18am ET |
| Benched | TE | Dawson Knox BUF | Owner | Wed Nov 26 12:18am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 12:18am ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Sun Nov 30 10:22am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Sun Nov 30 10:22am ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 8:27pm ET |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 8:27pm ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 8:27pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:27pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Sun Nov 30 11:11am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Sun Nov 30 11:11am ET |
| Benched | RB | Sean Tucker TB | Owner | Thu Nov 27 8:16am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 8:16am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 8:16am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 8:16am ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 12:53pm ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 12:53pm ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 12:51pm ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 12:51pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 12:51pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 12:51pm ET |
| Started | WR | Kayshon Boutte NE | Owner | Wed Nov 26 11:00pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 6:13pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 6:13pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 6:13pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 6:13pm ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 6:13pm ET |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 6:13pm ET |
| Benched | TE | Cade Otton TB | Owner | Tue Nov 25 6:13pm ET |
| Benched | WR | Cooper Kupp SEA | Owner | Tue Nov 25 6:13pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 6:13pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 12:31pm ET |
| Started | WR | Chris Olave NO | Owner | Thu Nov 27 12:31pm ET |
| Benched | WR | Chris Olave NO | Owner | Wed Nov 26 10:27pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Wed Nov 26 10:27pm ET |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 1:07pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Nov 25 1:07pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 1:07pm ET |
| Started | WR | George Pickens DAL | Owner | Tue Nov 25 1:07pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Sat Nov 29 9:59am ET |
| Benched | WR | Chimere Dike TEN | Owner | Sat Nov 29 9:59am ET |
| Started | WR | Chimere Dike TEN | Owner | Fri Nov 28 10:22am ET |
| Benched | WR | Parker Washington JAX | Owner | Fri Nov 28 10:22am ET |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 8:25pm ET |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 25 8:25pm ET |
| Started | QB | Jordan Love GB | Owner | Tue Nov 25 2:32pm ET |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 2:32pm ET |
| Started | WR | Christian Watson GB | Owner | Tue Nov 25 11:04am ET |
| Benched | WR | Adonai Mitchell NYJ | Owner | Tue Nov 25 11:04am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |