

| Started | RB | Rico Dowdle CAR | Owner | Fri Nov 28 9:06pm ET |
| Benched | WR | Stefon Diggs NE | Owner | Fri Nov 28 9:06pm ET |
| Started | QB | Tyrod Taylor NYJ | Owner | Fri Nov 28 9:04pm ET |
| Benched | QB | Kirk Cousins ATL | Owner | Fri Nov 28 9:04pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Thu Nov 27 4:34pm ET |
| Benched | RB | Rico Dowdle CAR | Owner | Thu Nov 27 4:34pm ET |
| Started | WR | Christian Watson GB | Owner | Thu Nov 27 9:13am ET |
| Benched | WR | Khalil Shakir BUF | Owner | Thu Nov 27 9:13am ET |
| Started | WR | Khalil Shakir BUF | Owner | Thu Nov 27 9:12am ET |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 9:12am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 9:12am ET |
| Benched | WR | Keenan Allen LAC | Owner | Thu Nov 27 9:12am ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 4:47pm ET |
| Benched | WR | Khalil Shakir BUF | Owner | Tue Nov 25 4:47pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 9:52pm ET |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 25 9:52pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 9:52pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:52pm ET |
| Benched | WR | Matthew Golden GB | Owner | Thu Nov 27 12:29pm ET |
| Started | WR | Gabriel Davis BUF | Owner | Thu Nov 27 12:29pm ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 10:30pm ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 10:30pm ET |
| Benched | WR | Gabriel Davis BUF | Owner | Tue Nov 25 1:06pm ET |
| Started | WR | Matthew Golden GB | Owner | Tue Nov 25 1:06pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:41pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Wed Nov 26 10:41pm ET |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 11:57pm ET |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 11:57pm ET |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 12:32pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Thu Nov 27 12:32pm ET |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 25 8:13pm ET |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 8:13pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:13pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 8:13pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 8:13pm ET |
| Benched | WR | Mack Hollins NE | Owner | Tue Nov 25 8:13pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 8:13pm ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 8:13pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 5:16pm ET |
| Benched | WR | Xavier Legette CAR | Owner | Wed Nov 26 5:16pm ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 5:16pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 5:16pm ET |
| Started | WR | Malik Washington MIA | Owner | Thu Nov 27 7:06am ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 6:04pm ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 6:04pm ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 6:04pm ET |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 6:04pm ET |
| Benched | QB | Malik Willis GB | Owner | Tue Nov 25 6:03pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 10:00am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 10:00am ET |
| No starting lineup changes performed this week. |
| Benched | TE | Colston Loveland CHI | Owner | Thu Nov 27 1:49am ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 1:49am ET |