

| Started | RB | Aaron Jones MIN | Owner | Wed Nov 26 11:48pm CT |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 11:48pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 7:09pm CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 7:09pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 7:09pm CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 25 7:09pm CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 7:09pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 7:09pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:01pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:01pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Thu Nov 27 3:34pm CT |
| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 3:34pm CT |
| Started | WR | Xavier Worthy KC | Owner | Thu Nov 27 8:11am CT |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 8:11am CT |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 25 3:45pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 3:45pm CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 3:44pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 3:44pm CT |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 3:44pm CT |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 3:44pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Shedeur Sanders CLE | Owner | Fri Nov 28 12:35pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Fri Nov 28 12:35pm CT |
| Benched | WR | Tyler Lockett LV | Owner | Tue Nov 25 12:30pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 12:30pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 12:30pm CT |
| Started | WR | Cedric Tillman CLE | Owner | Tue Nov 25 12:30pm CT |
| Benched | TE | George Kittle SF | Owner | Wed Nov 26 9:29pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 9:29pm CT |
| No starting lineup changes performed this week. |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Nov 25 5:15pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 5:15pm CT |
| Benched | WR | Darius Slayton NYG | Owner | Wed Nov 26 9:56pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 9:56pm CT |
| Benched | RB | Omarion Hampton LAC | Owner | Fri Nov 28 4:28pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Fri Nov 28 4:28pm CT |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 10:42am CT |
| Started | WR | Jameson Williams DET | Owner | Thu Nov 27 10:42am CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 11:37am CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 11:37am CT |
| Started | RB | Omarion Hampton LAC | Owner | Tue Nov 25 11:37am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 11:37am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 7:33pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 7:33pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 7:46pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 7:46pm CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 25 7:46pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 7:46pm CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Fri Nov 28 10:57am CT |
| Started | WR | John Metchie III NYJ | Owner | Fri Nov 28 10:57am CT |
| Benched | WR | Devaughn Vele NO | Owner | Wed Nov 26 12:55pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 12:55pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Sun Nov 30 12:29am CT |
| Started | WR | Darnell Mooney ATL | Owner | Sun Nov 30 12:29am CT |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 9:54pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 9:54pm CT |
| Benched | WR | Marquise Brown KC | Owner | Wed Nov 26 1:09am CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 1:09am CT |
| Benched | WR | Jaylin Noel HOU | Owner | Wed Nov 26 1:08am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 26 1:08am CT |