

| No starting lineup changes performed this week. |
| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 11:26am ET |
| Started | WR | Courtland Sutton DEN | Owner | Thu Nov 27 11:26am ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 2:16pm ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 25 2:16pm ET |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 1:58pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:58pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 4:32pm ET |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 27 4:32pm ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 10:38pm ET |
| Benched | TE | Dalton Schultz HOU | Owner | Wed Nov 26 10:38pm ET |
| Started | WR | Chris Godwin TB | Owner | Wed Nov 26 10:38pm ET |
| Started | TE | Brenton Strange JAX | Owner | Wed Nov 26 10:38pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 7:48pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 7:48pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 7:07pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 7:07pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 7:07pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 3:41pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 3:41pm ET |
| Benched | RB | Rico Dowdle CAR | Owner | Wed Nov 26 5:53pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 5:53pm ET |
| Benched | QB | Geno Smith LV | Owner | Wed Nov 26 5:30pm ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 5:30pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Fri Nov 28 2:34pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Fri Nov 28 2:34pm ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 8:02pm ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 8:02pm ET |
| Started | WR | Jordan Addison MIN | Owner | Thu Nov 27 8:01pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 8:01pm ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 25 11:31am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 11:31am ET |
| Benched | WR | Devaughn Vele NO | Owner | Thu Nov 27 9:08pm ET |
| Started | WR | Christian Kirk HOU | Owner | Thu Nov 27 9:08pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Wed Nov 26 5:01pm ET |
| Started | WR | Devaughn Vele NO | Owner | Wed Nov 26 5:01pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 12:52am ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 12:52am ET |
| Started | RB | Chuba Hubbard CAR | Owner | Wed Nov 26 12:52am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 12:52am ET |