

| Started | TE | Brenton Strange JAX | Owner | Sat Nov 29 1:50am ET |
| Benched | TE | T.J. Hockenson MIN | Owner | Sat Nov 29 1:50am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Sat Nov 29 1:49am ET |
| Benched | WR | Jordan Addison MIN | Owner | Sat Nov 29 1:49am ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 25 11:04am ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 11:04am ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 11:04am ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Nov 25 11:04am ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 11:04am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 11:04am ET |
| Benched | TE | Travis Kelce KC | Owner | Wed Nov 26 11:22pm ET |
| Started | RB | Quinshon Judkins CLE | Owner | Wed Nov 26 11:22pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 2:41am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 2:41am ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Detroit Lions DET | Owner | Wed Nov 26 8:36am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 8:36am ET |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Nov 26 8:36am ET |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 8:36am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 12:50am ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 10:58pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Wed Nov 26 10:58pm ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 2:00am ET |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 10:40pm ET |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 10:40pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 6:16pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 6:16pm ET |
| Benched | WR | Tre Tucker LV | Owner | Thu Nov 27 7:42am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 7:42am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 9:19am ET |
| Started | RB | Kyle Monangai CHI | Owner | Tue Nov 25 9:19am ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 9:18am ET |
| Started | WR | John Metchie III NYJ | Owner | Tue Nov 25 9:18am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 10:05am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 10:05am ET |
| No starting lineup changes performed this week. |