

| Benched | WR | Tez Johnson TB | Owner | Thu Oct 23 5:26pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Thu Oct 23 5:26pm CT |
| Started | K | Jake Moody CHI | Owner | Wed Oct 22 11:12pm CT |
| Benched | WR | Davante Adams LAR | Owner | Tue Oct 21 9:43am CT |
| Benched | TE | Sam LaPorta DET | Owner | Tue Oct 21 9:43am CT |
| Benched | TE | Trey McBride ARI | Owner | Tue Oct 21 9:43am CT |
| Started | RB | Derrick Henry BAL | Owner | Tue Oct 21 9:43am CT |
| Started | WR | Tez Johnson TB | Owner | Tue Oct 21 9:43am CT |
| Started | TE | Travis Kelce KC | Owner | Tue Oct 21 9:43am CT |
| Started | D/ST | Houston Texans HOU | Owner | Thu Oct 23 12:00am CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Oct 21 9:23am CT |
| Benched | TE | AJ Barner SEA | Owner | Tue Oct 21 9:23am CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Oct 21 9:23am CT |
| Started | TE | T.J. Hockenson MIN | Owner | Tue Oct 21 9:23am CT |
| Benched | RB | TreVeyon Henderson NE | Owner | Thu Oct 23 11:51pm CT |
| Started | WR | Tee Higgins CIN | Owner | Thu Oct 23 11:51pm CT |
| Benched | QB | Sam Darnold SEA | Owner | Wed Oct 22 4:20pm CT |
| Benched | WR | Jaxon Smith-Njigba SEA | Owner | Wed Oct 22 4:20pm CT |
| Started | QB | Lamar Jackson BAL | Owner | Wed Oct 22 4:20pm CT |
| Started | WR | Drake London ATL | Owner | Wed Oct 22 4:20pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Jahmyr Gibbs DET | Owner | Wed Oct 22 10:52am CT |
| Benched | RB | Ashton Jeanty LV | Owner | Wed Oct 22 10:52am CT |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Wed Oct 22 10:52am CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Oct 22 10:52am CT |
| Started | WR | Elic Ayomanor TEN | Owner | Wed Oct 22 10:52am CT |
| Started | TE | Colston Loveland CHI | Owner | Wed Oct 22 10:52am CT |
| Benched | RB | Kyren Williams LAR | Owner | Tue Oct 21 10:23am CT |
| Benched | TE | Darren Waller MIA | Owner | Tue Oct 21 10:23am CT |
| Started | WR | Zay Flowers BAL | Owner | Tue Oct 21 10:23am CT |
| Started | TE | Juwan Johnson NO | Owner | Tue Oct 21 10:23am CT |
| Started | WR | Calvin Austin III PIT | Owner | Fri Oct 24 5:31am CT |
| Benched | WR | Garrett Wilson NYJ | Owner | Fri Oct 24 5:31am CT |
| Started | D/ST | New England Patriots NE | Owner | Thu Oct 23 8:16am CT |
| Started | TE | Mark Andrews BAL | Owner | Wed Oct 22 12:42pm CT |
| Started | WR | Garrett Wilson NYJ | Owner | Wed Oct 22 12:42pm CT |
| Started | QB | Jalen Hurts PHI | Owner | Wed Oct 22 12:42pm CT |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Wed Oct 22 12:42pm CT |
| Benched | WR | Tre Tucker LV | Owner | Wed Oct 22 12:42pm CT |
| Benched | RB | Travis Etienne JAX | Owner | Wed Oct 22 12:42pm CT |
| Benched | QB | Jayden Daniels WAS | Owner | Wed Oct 22 12:42pm CT |
| Started | QB | Aaron Rodgers PIT | Owner | Thu Oct 23 10:58am CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Wed Oct 22 7:11pm CT |
| Benched | RB | Tony Pollard TEN | Owner | Wed Oct 22 7:11pm CT |
| Benched | WR | Kendrick Bourne SF | Owner | Wed Oct 22 7:11pm CT |
| Started | RB | D'Andre Swift CHI | Owner | Wed Oct 22 7:11pm CT |
| Started | WR | Romeo Doubs GB | Owner | Wed Oct 22 7:11pm CT |
| Started | K | Matt Prater BUF | Owner | Thu Oct 23 1:37pm CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Oct 21 7:22pm CT |
| Benched | K | Jason Myers SEA | Owner | Tue Oct 21 7:22pm CT |
| Started | WR | Xavier Legette CAR | Owner | Tue Oct 21 7:22pm CT |
| Benched | QB | Justin Fields NYJ | Owner | Tue Oct 21 3:14pm CT |
| Benched | WR | Mike Evans TB | Owner | Tue Oct 21 3:14pm CT |
| Benched | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 21 3:14pm CT |
| Started | QB | Josh Allen BUF | Owner | Tue Oct 21 3:14pm CT |
| Started | RB | Alvin Kamara NO | Owner | Tue Oct 21 3:14pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Oct 21 3:14pm CT |
| No starting lineup changes performed this week. |