

| Started | D/ST | Los Angeles Chargers LAC | Owner | Sun Nov 30 12:12pm ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 27 12:26pm ET |
| Started | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 27 12:25pm ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 27 3:54am ET |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 1:34am ET |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 27 1:34am ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 9:18am ET |
| Started | RB | Bijan Robinson ATL | Owner | Tue Nov 25 9:18am ET |
| Started | WR | Stefon Diggs NE | Owner | Tue Nov 25 9:18am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 9:18am ET |
| Started | TE | Travis Kelce KC | Owner | Tue Nov 25 9:18am ET |
| Started | K | Brandon Aubrey DAL | Owner | Tue Nov 25 9:18am ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 25 9:18am ET |
| Started | RB | Kareem Hunt KC | Owner | Tue Nov 25 9:18am ET |
| Started | QB | Dak Prescott DAL | Owner | Tue Nov 25 9:18am ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 9:16am ET |
| Benched | RB | Bijan Robinson ATL | Owner | Tue Nov 25 9:16am ET |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 9:16am ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 9:16am ET |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 9:16am ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 25 9:16am ET |
| Benched | K | Brandon Aubrey DAL | Owner | Tue Nov 25 9:16am ET |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 25 9:16am ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 25 9:16am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Sat Nov 29 11:56am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Sat Nov 29 11:56am ET |
| Started | WR | Deebo Samuel WAS | Owner | Sat Nov 29 9:56am ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Sat Nov 29 9:56am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 8:17pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 25 8:17pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 11:58am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 11:58am ET |
| Started | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 11:34am ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 11:34am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:08am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 9:08am ET |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 9:08am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 9:08am ET |
| No starting lineup changes performed this week. |
| Benched | K | Will Reichard MIN | Owner | Thu Nov 27 11:20am ET |
| Started | K | Wil Lutz DEN | Owner | Thu Nov 27 11:20am ET |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 4:50pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 4:50pm ET |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Thu Nov 27 7:40am ET |
| Started | TE | Dalton Kincaid BUF | Owner | Thu Nov 27 7:40am ET |
| Benched | TE | Pat Freiermuth PIT | Owner | Sat Nov 29 4:14pm ET |
| Started | TE | Darren Waller MIA | Owner | Sat Nov 29 4:14pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 8:54pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Wed Nov 26 8:54pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Courtland Sutton DEN | Owner | Thu Nov 27 12:32pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 12:32pm ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 11:09pm ET |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 11:09pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 11:09pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 11:09pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Thu Nov 27 9:28am ET |
| Started | WR | John Metchie III NYJ | Owner | Thu Nov 27 9:28am ET |
| Benched | QB | Davis Mills HOU | Owner | Wed Nov 26 7:25pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 7:25pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Wed Nov 26 7:25pm ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 7:25pm ET |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 7:25pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 7:25pm ET |
| Benched | QB | Matthew Stafford LAR | Owner | Tue Nov 25 11:36pm ET |
| Benched | WR | DeAndre Hopkins BAL | Owner | Tue Nov 25 11:36pm ET |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 25 11:36pm ET |
| Benched | K | Cam Little JAX | Owner | Tue Nov 25 11:36pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 11:36pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 11:36pm ET |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 25 11:36pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 11:36pm ET |