

| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 9:11am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 4 9:11am ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 4 9:11am ET |
| Benched | K | Harrison Butker KC | Owner | Tue Nov 4 9:11am ET |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Nov 4 9:11am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 9:11am ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 4 9:11am ET |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 9:39am ET |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 9:39am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 4 9:51pm ET |
| Benched | RB | Brashard Smith KC | Owner | Tue Nov 4 9:51pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 9:51pm ET |
| Benched | K | Wil Lutz DEN | Owner | Tue Nov 4 9:51pm ET |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 9:51pm ET |
| Started | RB | Rachaad White TB | Owner | Tue Nov 4 9:51pm ET |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 9:51pm ET |
| Started | K | Chase McLaughlin TB | Owner | Tue Nov 4 9:51pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Nov 4 9:18am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 4 9:18am ET |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 4 9:16am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 9:16am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 9:16am ET |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 9:16am ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 9:16am ET |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 4 9:16am ET |
| No starting lineup changes performed this week. |