

| Benched | WR | Courtland Sutton DEN | Owner | Tue Nov 18 2:06pm ET |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 18 2:06pm ET |
| Benched | RB | Josh Jacobs GB | Owner | Tue Nov 18 4:40pm ET |
| Started | RB | Tyler Allgeier ATL | Owner | Tue Nov 18 4:40pm ET |
| Benched | TE | Pat Freiermuth PIT | Owner | Tue Nov 18 9:44am ET |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Tue Nov 18 9:44am ET |
| Started | TE | Tyler Warren IND | Owner | Tue Nov 18 9:44am ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 18 9:44am ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 18 1:08pm ET |
| Started | QB | Jared Goff DET | Owner | Tue Nov 18 1:08pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 18 1:08pm ET |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 18 1:08pm ET |
| Started | K | Evan McPherson CIN | Owner | Thu Nov 20 2:01pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 19 11:17pm ET |
| Benched | WR | Ladd McConkey LAC | Owner | Wed Nov 19 11:17pm ET |
| Benched | K | Cameron Dicker LAC | Owner | Wed Nov 19 11:17pm ET |
| Started | RB | David Montgomery DET | Owner | Wed Nov 19 11:17pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Wed Nov 19 11:17pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Drake London ATL | Owner | Tue Nov 18 9:27am ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 18 9:27am ET |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 18 9:11am ET |
| Started | RB | Derrick Henry BAL | Owner | Tue Nov 18 9:11am ET |
| Started | D/ST | New England Patriots NE | Owner | Thu Nov 20 4:53pm ET |
| Benched | RB | Devon Achane MIA | Owner | Wed Nov 19 11:43am ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Wed Nov 19 11:43am ET |
| Started | RB | Woody Marks HOU | Owner | Wed Nov 19 11:43am ET |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 20 5:43am ET |
| Started | RB | Keaton Mitchell BAL | Owner | Thu Nov 20 5:43am ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 18 8:20pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 18 8:20pm ET |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 18 8:20pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 18 8:20pm ET |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 18 8:20pm ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 18 8:20pm ET |
| No starting lineup changes performed this week. |
| Started | K | Cam Little JAX | Owner | Thu Nov 20 8:21am ET |
| Benched | WR | Jayden Higgins HOU | Owner | Wed Nov 19 2:56pm ET |
| Started | WR | Chris Olave NO | Owner | Wed Nov 19 2:56pm ET |
| Started | D/ST | Houston Texans HOU | Owner | Thu Nov 20 4:46pm ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 20 4:46pm ET |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 20 12:17pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Thu Nov 20 12:17pm ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 20 5:45am ET |
| Benched | D/ST | Houston Texans HOU | Owner | Thu Nov 20 5:45am ET |
| Started | RB | Jonathan Taylor IND | Owner | Tue Nov 18 8:29am ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 18 8:29am ET |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 18 8:27am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 8:27am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 20 7:37am ET |