

| Benched | WR | Drake London ATL | Owner | Tue Nov 18 8:40pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 18 8:40pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 18 8:40pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 18 8:40pm ET |
| Benched | K | Eddy Pineiro SF | Owner | Tue Nov 18 8:53am ET |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 18 8:53am ET |
| Started | D/ST | Detroit Lions DET | Owner | Tue Nov 18 8:53am ET |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 19 2:14pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Wed Nov 19 2:14pm ET |
| Started | WR | Jameson Williams DET | Owner | Wed Nov 19 2:14pm ET |
| Benched | WR | A.J. Brown PHI | Owner | Wed Nov 19 2:14pm ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 18 4:23pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 18 4:23pm ET |
| Started | RB | Jonathan Taylor IND | Owner | Tue Nov 18 4:23pm ET |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 18 4:23pm ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 4:23pm ET |
| Benched | RB | Travis Etienne JAX | Owner | Tue Nov 18 4:23pm ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 19 9:54am ET |
| Started | RB | Alvin Kamara NO | Owner | Wed Nov 19 9:54am ET |
| Benched | QB | Dak Prescott DAL | Owner | Wed Nov 19 9:54am ET |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Wed Nov 19 9:54am ET |
| Started | QB | Jared Goff DET | Owner | Wed Nov 19 9:54am ET |
| Started | D/ST | Kansas City Chiefs KC | Owner | Wed Nov 19 9:54am ET |
| No starting lineup changes performed this week. |
| Started | RB | Chuba Hubbard CAR | Owner | Thu Nov 20 7:44am ET |
| Benched | QB | Justin Herbert LAC | Owner | Thu Nov 20 7:44am ET |
| Benched | RB | RJ Harvey DEN | Owner | Thu Nov 20 7:44am ET |
| Benched | WR | Calvin Ridley TEN | Owner | Thu Nov 20 7:44am ET |
| Started | TE | Noah Fant CIN | Owner | Thu Nov 20 7:44am ET |
| Benched | TE | Tyler Warren IND | Owner | Thu Nov 20 6:44am ET |
| Started | WR | Michael Wilson ARI | Owner | Thu Nov 20 6:44am ET |
| Started | K | Cairo Santos CHI | Owner | Thu Nov 20 6:43am ET |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 19 7:42am ET |
| Started | TE | Tyler Warren IND | Owner | Wed Nov 19 7:42am ET |
| Benched | RB | Jaylen Warren PIT | Owner | Wed Nov 19 7:42am ET |
| Started | RB | Sean Tucker TB | Owner | Wed Nov 19 7:42am ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Nov 18 7:23am ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 18 7:23am ET |
| Benched | RB | Devon Achane MIA | Owner | Tue Nov 18 12:07pm ET |
| Started | WR | Chris Olave NO | Owner | Tue Nov 18 12:07pm ET |
| No starting lineup changes performed this week. |
| Started | TE | Pat Freiermuth PIT | Owner | Thu Nov 20 9:12am ET |
| Benched | WR | Ladd McConkey LAC | Owner | Tue Nov 18 7:55pm ET |
| Benched | TE | Zach Ertz WAS | Owner | Tue Nov 18 7:55pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 18 7:55pm ET |
| Started | TE | Juwan Johnson NO | Owner | Wed Nov 19 9:56am ET |
| Benched | WR | Kendrick Bourne SF | Owner | Wed Nov 19 9:56am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 18 9:36am ET |
| Started | K | Chad Ryland ARI | Owner | Tue Nov 18 9:36am ET |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 18 9:36am ET |
| Started | WR | Kendrick Bourne SF | Owner | Tue Nov 18 9:36am ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Tue Nov 18 9:36am ET |
| Benched | K | Cameron Dicker LAC | Owner | Tue Nov 18 9:36am ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 18 9:36am ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 18 9:36am ET |
| Benched | WR | Courtland Sutton DEN | Owner | Wed Nov 19 8:15pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Wed Nov 19 8:15pm ET |
| Started | RB | David Montgomery DET | Owner | Wed Nov 19 8:15pm ET |
| Started | TE | Terrance Ferguson LAR | Owner | Wed Nov 19 8:15pm ET |