

| Started | TE | Zach Ertz WAS | Owner | Thu Nov 27 9:45am ET |
| Benched | TE | AJ Barner SEA | Owner | Thu Nov 27 4:17am ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 4:17am ET |
| Benched | WR | Drake London ATL | Owner | Thu Nov 27 4:15am ET |
| Started | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 4:15am ET |
| Started | D/ST | New England Patriots NE | Owner | Thu Nov 27 4:14am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 4:28pm ET |
| Started | WR | Drake London ATL | Owner | Wed Nov 26 4:28pm ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 12:02pm ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 12:02pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 5:03pm ET |
| Benched | WR | Tyrell Shavers BUF | Owner | Tue Nov 25 5:03pm ET |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Tue Nov 25 5:03pm ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 25 5:03pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 5:03pm ET |
| Started | TE | Evan Engram DEN | Owner | Tue Nov 25 5:03pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Thu Nov 27 12:31pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 12:31pm ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Thu Nov 27 12:29pm ET |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 12:29pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 8:23am ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 25 8:23am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 7:28pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 7:28pm ET |
| Benched | D/ST | San Francisco 49ers SF | Owner | Tue Nov 25 7:28pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:28pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 7:28pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 7:28pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 27 12:53am ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 12:53am ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 6:00pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 6:00pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 6:00pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 6:00pm ET |
| Benched | WR | Devaughn Vele NO | Owner | Fri Nov 28 11:58am ET |
| Started | WR | John Metchie III NYJ | Owner | Fri Nov 28 11:58am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 12:03pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 12:03pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 4:48am ET |
| Started | RB | Jaylen Warren PIT | Owner | Wed Nov 26 4:48am ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 12:10pm ET |
| Started | QB | Matthew Stafford LAR | Owner | Tue Nov 25 12:10pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 25 12:09pm ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 12:09pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 12:09pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 12:09pm ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 12:18pm ET |