

| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Oct 28 10:45am ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 10:45am ET |
| Benched | RB | Cam Skattebo NYG | Owner | Tue Oct 28 10:45am ET |
| Benched | WR | Matthew Golden GB | Owner | Tue Oct 28 10:45am ET |
| Benched | TE | Mason Taylor NYJ | Owner | Tue Oct 28 10:45am ET |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Oct 28 10:45am ET |
| Started | RB | Kyle Monangai CHI | Owner | Tue Oct 28 10:45am ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Oct 28 10:45am ET |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 10:45am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Baker Mayfield TB | Owner | Tue Oct 28 9:43pm ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Oct 28 9:43pm ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Oct 28 9:43pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 6:21pm ET |
| Started | QB | Brock Purdy SF | Owner | Tue Oct 28 6:21pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Rashid Shaheed NO | Owner | Tue Oct 28 1:32pm ET |
| Started | WR | Keon Coleman BUF | Owner | Tue Oct 28 1:32pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Spencer Rattler NO | Owner | Tue Oct 28 7:25am ET |
| Benched | K | Chase McLaughlin TB | Owner | Tue Oct 28 7:25am ET |
| Started | QB | Matthew Stafford LAR | Owner | Tue Oct 28 7:25am ET |
| Started | K | Blake Grupe NO | Owner | Tue Oct 28 7:25am ET |
| No starting lineup changes performed this week. |