

| Started | K | Harrison Mevis LAR | Owner | Fri Nov 28 7:14pm CT |
| Benched | WR | Zay Flowers BAL | Owner | Tue Nov 25 3:37pm CT |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 3:37pm CT |
| Started | WR | Stefon Diggs NE | Owner | Tue Nov 25 3:37pm CT |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 25 3:37pm CT |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 3:33pm CT |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 3:33pm CT |
| Started | WR | Zay Flowers BAL | Owner | Tue Nov 25 3:33pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 3:33pm CT |
| No starting lineup changes performed this week. |
| Started | TE | Dallas Goedert PHI | Owner | Wed Nov 26 10:32pm CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 4:33pm CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 4:33pm CT |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 5:56am CT |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 5:56am CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 5:56am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 5:56am CT |
| Benched | K | Eddy Pineiro SF | Owner | Thu Nov 27 12:32pm CT |
| Started | K | Cairo Santos CHI | Owner | Thu Nov 27 12:32pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Thu Nov 27 7:18am CT |
| Started | WR | Rashod Bateman BAL | Owner | Thu Nov 27 7:18am CT |
| Benched | RB | Kenneth Walker III SEA | Owner | Tue Nov 25 9:46pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:46pm CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 25 6:46am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 6:46am CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 9:39am CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Tue Nov 25 9:39am CT |
| Benched | WR | Marquise Brown KC | Owner | Wed Nov 26 10:59pm CT |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 10:59pm CT |