

| Benched | K | Andres Borregales NE | Owner | Sun Nov 30 1:50am ET |
| Started | K | Chase McLaughlin TB | Owner | Sun Nov 30 1:50am ET |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 10:12pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 10:12pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 10:11am ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 10:11am ET |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 25 10:41am ET |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 7:32am ET |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 25 7:32am ET |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 7:32am ET |
| Benched | WR | Tee Higgins CIN | Owner | Thu Nov 27 3:31am ET |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 3:31am ET |
| Benched | QB | Sam Darnold SEA | Owner | Thu Nov 27 3:21am ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 3:21am ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Nov 27 3:21am ET |
| Started | K | Evan McPherson CIN | Owner | Thu Nov 27 3:18am ET |
| Benched | RB | Jaylen Warren PIT | Owner | Wed Nov 26 3:16am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 3:16am ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 3:16am ET |
| Benched | K | Michael Badgley IND | Owner | Wed Nov 26 3:16am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 3:16am ET |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 3:16am ET |
| Started | RB | Devin Neal NO | Owner | Fri Nov 28 2:58pm ET |
| Benched | RB | Jordan Mason MIN | Owner | Fri Nov 28 2:58pm ET |
| Started | TE | Jake Ferguson DAL | Owner | Thu Nov 27 6:40am ET |
| Started | WR | Zay Flowers BAL | Owner | Thu Nov 27 6:40am ET |
| Started | WR | Davante Adams LAR | Owner | Thu Nov 27 6:40am ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 6:40am ET |
| Benched | TE | David Njoku CLE | Owner | Thu Nov 27 6:40am ET |
| Benched | WR | Parker Washington JAX | Owner | Thu Nov 27 6:40am ET |
| Benched | WR | Malik Washington MIA | Owner | Thu Nov 27 6:40am ET |
| Benched | RB | Devin Neal NO | Owner | Thu Nov 27 6:40am ET |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 25 1:55pm ET |
| Benched | WR | Cedric Tillman CLE | Owner | Tue Nov 25 1:55pm ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 1:54pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 1:54pm ET |
| Started | WR | Luther Burden III CHI | Owner | Thu Nov 27 6:19pm ET |
| Benched | WR | Terry McLaurin WAS | Owner | Thu Nov 27 6:19pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Thu Nov 27 6:06pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Thu Nov 27 6:06pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 5:02pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Wed Nov 26 5:02pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 5:02pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 5:02pm ET |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Wed Nov 26 5:02pm ET |
| Benched | K | Matt Prater BUF | Owner | Wed Nov 26 5:02pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Wed Nov 26 5:02pm ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 5:02pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 11:35pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 11:35pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 11:35pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 11:35pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Jameson Williams DET | Owner | Thu Nov 27 6:30am ET |
| Started | WR | Rashee Rice KC | Owner | Thu Nov 27 6:30am ET |
| Started | QB | Kirk Cousins ATL | Owner | Thu Nov 27 6:27am ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 11:05am ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 25 11:05am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 25 11:05am ET |
| Started | TE | Travis Kelce KC | Owner | Thu Nov 27 4:12pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 4:12pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Thu Nov 27 4:04pm ET |
| Benched | TE | Travis Kelce KC | Owner | Thu Nov 27 4:04pm ET |
| Started | TE | Travis Kelce KC | Owner | Thu Nov 27 1:09am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 1:09am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 1:59pm ET |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 25 1:59pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 1:59pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 1:59pm ET |