

| Benched | RB | Kenneth Gainwell PIT | Owner | Sun Nov 30 8:19am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sun Nov 30 8:19am CT |
| Benched | TE | Dalton Kincaid BUF | Owner | Thu Nov 27 10:31am CT |
| Started | TE | Colby Parkinson LAR | Owner | Thu Nov 27 10:31am CT |
| Benched | TE | Michael Mayer LV | Owner | Tue Nov 25 7:35pm CT |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 25 7:35pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 6:55am CT |
| Started | QB | C.J. Stroud HOU | Owner | Wed Nov 26 9:29pm CT |
| Started | D/ST | Baltimore Ravens BAL | Owner | Wed Nov 26 8:03am CT |
| Started | RB | Quinshon Judkins CLE | Owner | Wed Nov 26 8:03am CT |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 25 10:53am CT |
| Started | K | Jake Bates DET | Owner | Tue Nov 25 7:09am CT |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 7:08am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 7:08am CT |
| Started | RB | Christian McCaffrey SF | Owner | Tue Nov 25 7:08am CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Nov 25 7:08am CT |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Tue Nov 25 6:12am CT |
| Benched | K | Jake Bates DET | Owner | Tue Nov 25 6:12am CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 6:12am CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 6:12am CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 6:12am CT |
| Benched | RB | Christian McCaffrey SF | Owner | Tue Nov 25 6:12am CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 6:12am CT |
| Benched | RB | Ashton Jeanty LV | Owner | Tue Nov 25 6:12am CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 6:12am CT |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 9:52pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Wed Nov 26 9:52pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Fri Nov 28 6:25pm CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Fri Nov 28 6:25pm CT |
| Benched | WR | Tetairoa McMillan CAR | Owner | Fri Nov 28 6:25pm CT |
| Benched | RB | Jordan Mason MIN | Owner | Fri Nov 28 6:25pm CT |
| Started | D/ST | Atlanta Falcons ATL | Owner | Wed Nov 26 8:54am CT |
| Benched | D/ST | Chicago Bears CHI | Owner | Wed Nov 26 8:54am CT |
| Started | RB | Jordan Mason MIN | Owner | Tue Nov 25 5:06pm CT |
| Started | QB | Jordan Love GB | Owner | Tue Nov 25 5:05pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 5:05pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:02pm CT |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 5:02pm CT |
| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 25 5:02pm CT |
| Benched | QB | Jared Goff DET | Owner | Wed Nov 26 5:49am CT |
| Benched | WR | Keon Coleman BUF | Owner | Wed Nov 26 5:49am CT |
| Benched | WR | Tyquan Thornton KC | Owner | Wed Nov 26 5:49am CT |
| Benched | K | Cam Little JAX | Owner | Wed Nov 26 5:49am CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 5:49am CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 5:49am CT |
| Started | WR | Darius Slayton NYG | Owner | Wed Nov 26 5:49am CT |
| Started | K | Chase McLaughlin TB | Owner | Wed Nov 26 5:49am CT |
| Started | WR | Adonai Mitchell NYJ | Owner | Thu Nov 27 12:57am CT |
| Benched | WR | Quentin Johnston LAC | Owner | Thu Nov 27 12:57am CT |
| Started | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 8:21pm CT |
| Benched | RB | Isaiah Davis NYJ | Owner | Tue Nov 25 8:21pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 8:21pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 8:21pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 8:21pm CT |
| Started | RB | Isaiah Davis NYJ | Owner | Tue Nov 25 8:21pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:21pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 8:21pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 8:21pm CT |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 8:21pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 8:21pm CT |
| Benched | QB | Tyrod Taylor NYJ | Owner | Tue Nov 25 8:21pm CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 12:20am CT |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Nov 25 1:45pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 1:45pm CT |
| Started | D/ST | San Francisco 49ers SF | Owner | Thu Nov 27 6:45am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 7:25am CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 7:25am CT |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 26 7:25am CT |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 7:25am CT |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Sun Nov 30 8:23am CT |
| Benched | D/ST | Denver Broncos DEN | Owner | Sun Nov 30 8:23am CT |
| Started | WR | Chimere Dike TEN | Owner | Thu Nov 27 8:16am CT |
| Benched | WR | Jordan Addison MIN | Owner | Thu Nov 27 8:16am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 6:21pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 6:21pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 6:21pm CT |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Wed Nov 26 6:21pm CT |
| Benched | WR | Chimere Dike TEN | Owner | Wed Nov 26 6:21pm CT |
| Benched | QB | Caleb Williams CHI | Owner | Wed Nov 26 6:21pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 9:57am CT |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 9:57am CT |
| Started | QB | Daniel Jones IND | Owner | Wed Nov 26 9:57am CT |
| Benched | QB | Joe Burrow CIN | Owner | Wed Nov 26 9:57am CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 8:40am CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 25 8:40am CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 25 8:39am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 8:39am CT |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 25 8:39am CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Nov 25 8:39am CT |
| Benched | RB | Devin Neal NO | Owner | Thu Nov 27 7:10am CT |
| Started | RB | David Montgomery DET | Owner | Thu Nov 27 7:10am CT |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 10:07am CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 10:07am CT |
| Benched | K | Chad Ryland ARI | Owner | Tue Nov 25 8:14am CT |
| Started | K | Wil Lutz DEN | Owner | Tue Nov 25 8:14am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 8:11am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 8:11am CT |
| No starting lineup changes performed this week. |