

| Benched | QB | Brock Purdy SF | Owner | Thu Nov 27 12:38am CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 12:38am CT |
| Started | WR | Parker Washington JAX | Owner | Wed Nov 26 12:07pm CT |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 12:07pm CT |
| Benched | K | Tyler Loop BAL | Owner | Wed Nov 26 4:39pm CT |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 4:39pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 4:37pm CT |
| Started | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 4:37pm CT |
| Benched | TE | Cade Otton TB | Owner | Sun Nov 30 11:49am CT |
| Started | TE | Kyle Pitts ATL | Owner | Sun Nov 30 11:49am CT |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 25 5:03pm CT |
| Started | TE | Cade Otton TB | Owner | Tue Nov 25 5:03pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 25 11:05am CT |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 11:05am CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 11:05am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 11:05am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Thu Nov 27 11:19am CT |
| Benched | RB | Kyren Williams LAR | Owner | Thu Nov 27 11:19am CT |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 11:19am CT |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 11:19am CT |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 8:06am CT |
| Benched | RB | Jaylen Warren PIT | Owner | Wed Nov 26 8:06am CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 8:06am CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 8:06am CT |
| Benched | RB | Bhayshul Tuten JAX | Owner | Sun Nov 30 11:42am CT |
| Started | RB | Zonovan Knight ARI | Owner | Sun Nov 30 11:42am CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Sun Nov 30 1:52am CT |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Thu Nov 27 7:13pm CT |
| Benched | WR | Justin Jefferson MIN | Owner | Thu Nov 27 11:40am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 11:40am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Thu Nov 27 11:39am CT |
| Started | RB | Bhayshul Tuten JAX | Owner | Thu Nov 27 11:39am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Sun Nov 30 10:36am CT |
| Started | WR | Chris Olave NO | Owner | Sun Nov 30 10:36am CT |
| Benched | WR | Chris Olave NO | Owner | Sun Nov 30 8:37am CT |
| Started | WR | Quentin Johnston LAC | Owner | Sun Nov 30 8:37am CT |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 6:24pm CT |
| Benched | TE | Theo Johnson NYG | Owner | Wed Nov 26 6:24pm CT |
| Started | QB | Caleb Williams CHI | Owner | Wed Nov 26 6:24pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 6:24pm CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 8:04am CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 8:04am CT |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 8:04am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 8:04am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:04am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:04am CT |
| Benched | QB | Joe Flacco CIN | Owner | Wed Nov 26 10:54am CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 10:54am CT |
| Started | QB | Aaron Rodgers PIT | Owner | Wed Nov 26 10:54am CT |
| Started | WR | Khalil Shakir BUF | Owner | Wed Nov 26 10:54am CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 10:53pm CT |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 10:53pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 10:53pm CT |
| Started | WR | Michael Wilson ARI | Owner | Tue Nov 25 10:53pm CT |
| No starting lineup changes performed this week. |