

| Benched | WR | Josh Downs IND | Owner | Thu Nov 27 8:47am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Thu Nov 27 8:47am CT |
| Benched | WR | Alec Pierce IND | Owner | Thu Nov 27 8:47am CT |
| Started | WR | Keenan Allen LAC | Owner | Thu Nov 27 8:47am CT |
| Started | WR | Kayshon Boutte NE | Owner | Thu Nov 27 8:47am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 8:47am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 2:00pm CT |
| Benched | K | Michael Badgley IND | Owner | Tue Nov 25 2:00pm CT |
| Benched | D/ST | Green Bay Packers GB | Owner | Tue Nov 25 2:00pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 2:00pm CT |
| Started | K | Harrison Butker KC | Owner | Tue Nov 25 2:00pm CT |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 25 2:00pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Wed Nov 26 1:57am CT |
| Benched | WR | Kendrick Bourne SF | Owner | Wed Nov 26 1:57am CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 1:57am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 1:57am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 10:10am CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 10:10am CT |
| Started | D/ST | Atlanta Falcons ATL | Owner | Wed Nov 26 11:05pm CT |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 1:23pm CT |
| Started | RB | Tyjae Spears TEN | Owner | Wed Nov 26 1:23pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 8:52am CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 8:52am CT |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 10:54am CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 25 10:54am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 10:54am CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 10:54am CT |
| Started | WR | Emeka Egbuka TB | Owner | Thu Nov 27 5:11am CT |
| Benched | WR | Chris Olave NO | Owner | Thu Nov 27 5:11am CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Wed Nov 26 4:51am CT |
| Started | TE | Harold Fannin Jr. CLE | Owner | Wed Nov 26 4:51am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 4:51am CT |
| Started | QB | Daniel Jones IND | Owner | Wed Nov 26 4:51am CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 4:51am CT |
| Benched | TE | Cade Otton TB | Owner | Wed Nov 26 4:51am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Nov 26 4:51am CT |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 4:51am CT |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 2:18pm CT |
| Started | WR | Michael Wilson ARI | Owner | Tue Nov 25 2:18pm CT |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 25 2:07pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 2:07pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 7:23am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:23am CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 7:23am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 7:23am CT |
| Benched | QB | Jaxson Dart NYG | Owner | Thu Nov 27 8:44am CT |
| Benched | RB | Zavier Scott MIN | Owner | Thu Nov 27 8:44am CT |
| Benched | TE | Colston Loveland CHI | Owner | Thu Nov 27 8:44am CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 8:44am CT |
| Started | RB | Kimani Vidal LAC | Owner | Thu Nov 27 8:44am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 8:44am CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Thu Nov 27 11:16am CT |
| Benched | WR | Darius Slayton NYG | Owner | Thu Nov 27 11:16am CT |
| Started | RB | Tony Pollard TEN | Owner | Thu Nov 27 11:16am CT |
| Started | TE | Mark Andrews BAL | Owner | Thu Nov 27 11:16am CT |