

| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 2:47pm CT |
| Started | RB | David Montgomery DET | Owner | Wed Nov 26 2:47pm CT |
| Benched | D/ST | New Orleans Saints NO | Owner | Tue Nov 25 11:48am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 11:48am CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 11:48am CT |
| Started | RB | Tony Pollard TEN | Owner | Tue Nov 25 11:48am CT |
| Benched | WR | Cooper Kupp SEA | Owner | Thu Nov 27 8:24am CT |
| Started | WR | Keon Coleman BUF | Owner | Thu Nov 27 8:24am CT |
| Benched | QB | Kirk Cousins ATL | Owner | Wed Nov 26 8:09am CT |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 8:09am CT |
| Benched | WR | Xavier Hutchinson HOU | Owner | Wed Nov 26 8:09am CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 8:09am CT |
| Started | RB | Kareem Hunt KC | Owner | Wed Nov 26 8:09am CT |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 8:09am CT |
| Started | K | Jake Bates DET | Owner | Wed Nov 26 11:36pm CT |
| Benched | RB | Kenneth Walker III SEA | Owner | Tue Nov 25 12:57pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 12:57pm CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 25 12:57pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 25 12:57pm CT |
| Benched | WR | Drake London ATL | Owner | Thu Nov 27 7:49pm CT |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 7:49pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 4:42pm CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 4:42pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 7:54pm CT |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 7:54pm CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Thu Nov 27 10:05am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 10:05am CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 5:41pm CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 5:41pm CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 2:08pm CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 2:08pm CT |
| Benched | K | Andres Borregales NE | Owner | Tue Nov 25 2:08pm CT |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 25 2:08pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 1:48pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 1:48pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 1:48pm CT |
| Benched | WR | Chris Godwin TB | Owner | Tue Nov 25 1:48pm CT |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 1:48pm CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 1:48pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 10:33am CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 25 10:33am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 10:33am CT |
| Started | TE | Brenton Strange JAX | Owner | Tue Nov 25 10:33am CT |
| Benched | QB | Baker Mayfield TB | Owner | Thu Nov 27 10:59am CT |
| Started | QB | Jordan Love GB | Owner | Thu Nov 27 10:59am CT |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 6:08am CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 6:08am CT |
| Benched | TE | Travis Kelce KC | Owner | Wed Nov 26 8:10am CT |
| Started | RB | Jaylen Warren PIT | Owner | Wed Nov 26 8:10am CT |
| Benched | TE | AJ Barner SEA | Owner | Thu Nov 27 6:20am CT |
| Started | TE | Kyle Pitts ATL | Owner | Thu Nov 27 6:20am CT |
| Benched | WR | Jameson Williams DET | Owner | Wed Nov 26 8:49am CT |
| Started | WR | Stefon Diggs NE | Owner | Wed Nov 26 8:49am CT |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 25 6:22pm CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 25 6:22pm CT |
| No starting lineup changes performed this week. |