

| Started | WR | Tyrell Shavers BUF | Owner | Thu Nov 20 11:05am ET |
| Started | D/ST | Indianapolis Colts IND | Owner | Thu Nov 20 11:04am ET |
| Started | K | Andres Borregales NE | Owner | Thu Nov 20 11:04am ET |
| Benched | WR | Keon Coleman BUF | Owner | Thu Nov 20 11:04am ET |
| Started | WR | Keon Coleman BUF | Owner | Tue Nov 18 10:57am ET |
| Started | RB | Woody Marks HOU | Owner | Tue Nov 18 10:57am ET |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Tue Nov 18 10:56am ET |
| Benched | K | Eddy Pineiro SF | Owner | Tue Nov 18 10:56am ET |
| Benched | WR | Troy Franklin DEN | Owner | Tue Nov 18 10:56am ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 18 10:56am ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 18 11:10am ET |
| Started | D/ST | Green Bay Packers GB | Owner | Tue Nov 18 11:10am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Thu Nov 20 12:12pm ET |
| Benched | RB | Emari Demercado ARI | Owner | Tue Nov 18 8:25pm ET |
| Started | RB | Bhayshul Tuten JAX | Owner | Tue Nov 18 8:25pm ET |
| Benched | RB | Josh Jacobs GB | Owner | Wed Nov 19 7:34pm ET |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 19 7:34pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 19 7:34pm ET |
| Started | RB | David Montgomery DET | Owner | Wed Nov 19 7:34pm ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 18 10:00pm ET |
| Benched | WR | Keenan Allen LAC | Owner | Tue Nov 18 10:00pm ET |
| Benched | TE | Zach Ertz WAS | Owner | Tue Nov 18 10:00pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 18 10:00pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 18 10:00pm ET |
| Started | TE | T.J. Hockenson MIN | Owner | Tue Nov 18 10:00pm ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 9:34am ET |
| Benched | WR | Courtland Sutton DEN | Owner | Tue Nov 18 9:34am ET |
| Benched | TE | David Njoku CLE | Owner | Tue Nov 18 9:34am ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Tue Nov 18 9:34am ET |
| Started | RB | Kareem Hunt KC | Owner | Tue Nov 18 9:34am ET |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 18 9:34am ET |
| Started | TE | Tyler Warren IND | Owner | Tue Nov 18 9:34am ET |
| Started | D/ST | Detroit Lions DET | Owner | Tue Nov 18 9:34am ET |
| Benched | WR | Calvin Austin III PIT | Owner | Thu Nov 20 11:02am ET |
| Benched | WR | Xavier Hutchinson HOU | Owner | Thu Nov 20 11:02am ET |
| Started | WR | Chimere Dike TEN | Owner | Thu Nov 20 11:02am ET |
| Started | WR | Greg Dortch ARI | Owner | Thu Nov 20 11:02am ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 19 2:23am ET |
| Benched | RB | Devon Achane MIA | Owner | Wed Nov 19 2:23am ET |
| Started | QB | Brock Purdy SF | Owner | Wed Nov 19 2:23am ET |
| Started | WR | Xavier Hutchinson HOU | Owner | Wed Nov 19 2:23am ET |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Thu Nov 20 2:45am ET |
| Benched | WR | Deebo Samuel WAS | Owner | Thu Nov 20 2:45am ET |
| Started | RB | Brian Robinson Jr. SF | Owner | Thu Nov 20 2:45am ET |
| Started | WR | Alec Pierce IND | Owner | Thu Nov 20 2:45am ET |
| No starting lineup changes performed this week. |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 18 11:46am ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 18 11:46am ET |
| Started | RB | Tyjae Spears TEN | Owner | Tue Nov 18 11:46am ET |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 18 11:46am ET |
| Benched | QB | Bo Nix DEN | Owner | Tue Nov 18 9:18am ET |
| Benched | RB | Jerome Ford CLE | Owner | Tue Nov 18 9:18am ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Nov 18 9:18am ET |
| Started | QB | Matthew Stafford LAR | Owner | Tue Nov 18 9:18am ET |
| Started | RB | Jonathan Taylor IND | Owner | Tue Nov 18 9:18am ET |
| Started | WR | Christian Watson GB | Owner | Tue Nov 18 9:18am ET |