

| Benched | D/ST | Detroit Lions DET | Owner | Wed Dec 10 8:26pm CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Wed Dec 10 8:26pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Dec 10 8:31pm CT |
| Benched | TE | Darren Waller MIA | Owner | Wed Dec 10 8:31pm CT |
| Started | WR | Jauan Jennings SF | Owner | Wed Dec 10 8:31pm CT |
| Started | TE | George Kittle SF | Owner | Wed Dec 10 8:31pm CT |
| Benched | QB | Tua Tagovailoa MIA | Owner | Wed Dec 10 7:19pm CT |
| Started | QB | Bryce Young CAR | Owner | Wed Dec 10 7:19pm CT |
| Benched | WR | Jayden Reed GB | Owner | Tue Dec 9 2:36pm CT |
| Benched | TE | Cade Otton TB | Owner | Tue Dec 9 2:36pm CT |
| Started | RB | Zonovan Knight ARI | Owner | Tue Dec 9 2:36pm CT |
| Started | TE | Theo Johnson NYG | Owner | Tue Dec 9 2:36pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Dec 9 7:55am CT |
| Started | WR | Jayden Reed GB | Owner | Tue Dec 9 7:55am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Dec 9 7:55am CT |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Dec 9 7:55am CT |
| Benched | QB | Bo Nix DEN | Owner | Thu Dec 11 7:07pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Thu Dec 11 7:07pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Wed Dec 10 1:39pm CT |
| Benched | WR | Malik Washington MIA | Owner | Wed Dec 10 1:39pm CT |
| Started | RB | Rico Dowdle CAR | Owner | Wed Dec 10 1:39pm CT |
| Started | WR | Stefon Diggs NE | Owner | Wed Dec 10 1:39pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Thu Dec 11 5:17pm CT |
| Started | RB | Chuba Hubbard CAR | Owner | Thu Dec 11 5:17pm CT |
| Started | D/ST | Carolina Panthers CAR | Owner | Thu Dec 11 5:16pm CT |
| Benched | WR | Dontayvion Wicks GB | Owner | Wed Dec 10 5:17pm CT |
| Benched | K | Nick Folk NYJ | Owner | Wed Dec 10 5:17pm CT |
| Started | WR | Elic Ayomanor TEN | Owner | Wed Dec 10 5:17pm CT |
| Started | K | Tyler Loop BAL | Owner | Wed Dec 10 5:17pm CT |
| Started | WR | Chimere Dike TEN | Owner | Thu Dec 11 3:41pm CT |
| Benched | RB | David Montgomery DET | Owner | Thu Dec 11 3:41pm CT |
| Started | RB | David Montgomery DET | Owner | Thu Dec 11 3:39pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Thu Dec 11 3:39pm CT |
| Started | TE | Kyle Pitts ATL | Owner | Thu Dec 11 3:36pm CT |
| Benched | TE | Colston Loveland CHI | Owner | Thu Dec 11 3:36pm CT |
| Started | D/ST | Chicago Bears CHI | Owner | Thu Dec 11 8:28am CT |
| Started | RB | Devin Singletary NYG | Owner | Tue Dec 9 6:10pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Dec 9 6:10pm CT |
| Benched | RB | David Montgomery DET | Owner | Tue Dec 9 6:10pm CT |
| Benched | QB | Caleb Williams CHI | Owner | Tue Dec 9 6:10pm CT |
| Benched | QB | Jared Goff DET | Owner | Wed Dec 10 5:32pm CT |
| Benched | WR | Troy Franklin DEN | Owner | Wed Dec 10 5:32pm CT |
| Started | QB | Dak Prescott DAL | Owner | Wed Dec 10 5:32pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Wed Dec 10 5:32pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Justin Jefferson MIN | Owner | Fri Dec 12 7:30pm CT |
| Started | WR | Michael Wilson ARI | Owner | Fri Dec 12 7:30pm CT |
| Benched | WR | Michael Wilson ARI | Owner | Wed Dec 10 8:10pm CT |
| Started | WR | Justin Jefferson MIN | Owner | Wed Dec 10 8:10pm CT |
| Benched | RB | Kenneth Walker III SEA | Owner | Tue Dec 9 11:46am CT |
| Started | RB | Omarion Hampton LAC | Owner | Tue Dec 9 11:46am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Thu Dec 11 2:45am CT |
| Benched | WR | Deebo Samuel WAS | Owner | Thu Dec 11 2:45am CT |
| Started | QB | Brock Purdy SF | Owner | Thu Dec 11 2:45am CT |
| Started | RB | Christian McCaffrey SF | Owner | Thu Dec 11 2:45am CT |