

| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 4:56pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:56pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Rome Odunze CHI | Owner | Wed Nov 26 5:07pm CT |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 5:07pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Fri Nov 28 11:39am CT |
| Benched | RB | Chris Rodriguez Jr. WAS | Owner | Fri Nov 28 11:39am CT |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Fri Nov 28 11:37am CT |
| Benched | RB | Trey Benson ARI | Owner | Fri Nov 28 11:37am CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 11:47am CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 11:47am CT |
| Started | RB | Trey Benson ARI | Owner | Tue Nov 25 11:47am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 11:47am CT |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 11:47am CT |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 11:47am CT |
| Benched | QB | Shedeur Sanders CLE | Owner | Tue Nov 25 12:58pm CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 12:58pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 12:58pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 12:58pm CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Sat Nov 29 5:59pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 5:59pm CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 1:01am CT |
| Benched | RB | Kimani Vidal LAC | Owner | Wed Nov 26 9:41pm CT |
| Started | RB | Aaron Jones MIN | Owner | Wed Nov 26 9:41pm CT |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 25 5:18pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 25 5:18pm CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Nov 25 4:49pm CT |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 4:49pm CT |
| Benched | RB | Chuba Hubbard CAR | Owner | Wed Nov 26 8:05am CT |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 8:05am CT |
| Benched | QB | C.J. Stroud HOU | Owner | Thu Nov 27 7:58am CT |
| Started | QB | Jordan Love GB | Owner | Thu Nov 27 7:58am CT |
| Benched | QB | Jordan Love GB | Owner | Wed Nov 26 10:40pm CT |
| Started | QB | C.J. Stroud HOU | Owner | Wed Nov 26 10:40pm CT |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 9:46am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:46am CT |
| Benched | WR | Justin Jefferson MIN | Owner | Wed Nov 26 9:20pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 9:20pm CT |
| Started | D/ST | Dallas Cowboys DAL | Owner | Thu Nov 27 6:56am CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 3:46pm CT |
| Benched | WR | Luther Burden III CHI | Owner | Tue Nov 25 3:46pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 3:46pm CT |
| Benched | K | Cairo Santos CHI | Owner | Tue Nov 25 3:46pm CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 3:46pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 3:46pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 3:46pm CT |
| Started | K | Harrison Butker KC | Owner | Tue Nov 25 3:46pm CT |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 1:00am CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 1:00am CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 1:00am CT |
| Benched | D/ST | Arizona Cardinals ARI | Owner | Wed Nov 26 1:00am CT |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 1:00am CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 1:00am CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 1:00am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 1:00am CT |