

| Benched | QB | Patrick Mahomes KC | Owner | Wed Dec 10 11:44pm ET |
| Benched | RB | Breece Hall NYJ | Owner | Wed Dec 10 11:44pm ET |
| Started | QB | Lamar Jackson BAL | Owner | Wed Dec 10 11:44pm ET |
| Started | RB | Saquon Barkley PHI | Owner | Wed Dec 10 11:44pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Sat Dec 13 1:55pm ET |
| Started | WR | Jauan Jennings SF | Owner | Sat Dec 13 1:55pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Fri Dec 12 1:30pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Fri Dec 12 1:30pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Wed Dec 10 4:48pm ET |
| Started | WR | Tee Higgins CIN | Owner | Wed Dec 10 4:48pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Dec 9 9:10am ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Dec 9 9:10am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Quentin Johnston LAC | Owner | Thu Dec 11 12:47pm ET |
| Started | WR | Keenan Allen LAC | Owner | Thu Dec 11 12:47pm ET |
| Benched | QB | Jared Goff DET | Owner | Thu Dec 11 12:46pm ET |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Thu Dec 11 12:46pm ET |
| Started | QB | Sam Darnold SEA | Owner | Thu Dec 11 12:46pm ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Thu Dec 11 12:46pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Dec 10 10:56am ET |
| Started | RB | Christian McCaffrey SF | Owner | Wed Dec 10 10:56am ET |
| Benched | QB | Shedeur Sanders CLE | Owner | Thu Dec 11 8:50am ET |
| Benched | WR | Luther Burden III CHI | Owner | Thu Dec 11 8:50am ET |
| Started | QB | Jaxson Dart NYG | Owner | Thu Dec 11 8:50am ET |
| Started | WR | Tetairoa McMillan CAR | Owner | Thu Dec 11 8:50am ET |
| Benched | QB | Caleb Williams CHI | Owner | Thu Dec 11 7:47am ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Thu Dec 11 7:47am ET |
| Started | QB | Drake Maye NE | Owner | Thu Dec 11 7:47am ET |
| Started | D/ST | New York Giants NYG | Owner | Thu Dec 11 7:47am ET |
| Benched | TE | Darren Waller MIA | Owner | Tue Dec 9 9:20am ET |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Dec 9 9:20am ET |
| Started | K | Jake Bates DET | Owner | Sun Dec 14 1:00am ET |
| Started | D/ST | Dallas Cowboys DAL | Owner | Sun Dec 14 1:00am ET |
| Benched | WR | Jayden Reed GB | Owner | Tue Dec 9 5:15pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Dec 9 5:15pm ET |
| Started | RB | Rico Dowdle CAR | Owner | Tue Dec 9 5:15pm ET |
| Started | TE | Colston Loveland CHI | Owner | Tue Dec 9 5:15pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Bo Nix DEN | Owner | Thu Dec 11 7:11pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Thu Dec 11 7:11pm ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Dec 9 10:02pm ET |
| Benched | TE | Mike Gesicki CIN | Owner | Tue Dec 9 10:02pm ET |
| Started | RB | Omarion Hampton LAC | Owner | Tue Dec 9 10:02pm ET |
| Started | TE | George Kittle SF | Owner | Tue Dec 9 10:02pm ET |