

| Started | D/ST | Indianapolis Colts IND | Owner | Thu Nov 27 8:45am CT |
| Benched | TE | Hunter Henry NE | Owner | Wed Nov 26 10:31pm CT |
| Started | TE | Brenton Strange JAX | Owner | Wed Nov 26 10:31pm CT |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 10:31pm CT |
| Benched | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 10:31pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 10:31pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 10:31pm CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 10:31pm CT |
| Started | WR | Michael Pittman Jr. IND | Owner | Wed Nov 26 10:31pm CT |
| Benched | RB | Zonovan Knight ARI | Owner | Sat Nov 29 9:54pm CT |
| Started | RB | RJ Harvey DEN | Owner | Sat Nov 29 9:54pm CT |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 11:03am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 11:03am CT |
| Benched | WR | Parker Washington JAX | Owner | Wed Nov 26 7:21am CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 7:21am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 6:16am CT |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 25 6:16am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 6:16am CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 25 6:16am CT |
| Benched | RB | Aaron Jones MIN | Owner | Thu Nov 27 2:58am CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Thu Nov 27 2:58am CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 9:08am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 9:08am CT |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 25 10:17pm CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 25 10:17pm CT |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 11:13pm CT |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Wed Nov 26 11:13pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 11:13pm CT |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Wed Nov 26 11:13pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Wed Nov 26 9:09pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 9:09pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 8:54pm CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:54pm CT |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 8:54pm CT |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 25 8:54pm CT |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 8:54pm CT |
| Started | QB | Jordan Love GB | Owner | Tue Nov 25 8:54pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 8:54pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 8:54pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 26 11:08pm CT |
| Started | D/ST | Atlanta Falcons ATL | Owner | Wed Nov 26 11:07pm CT |
| Started | QB | Drake Maye NE | Owner | Wed Nov 26 11:07pm CT |
| Benched | TE | Mark Andrews BAL | Owner | Wed Nov 26 8:08am CT |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 26 8:08am CT |
| Started | RB | Kenneth Gainwell PIT | Owner | Tue Nov 25 7:44am CT |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 6:16am CT |
| Started | TE | Trey McBride ARI | Owner | Tue Nov 25 6:16am CT |
| Started | WR | Justin Jefferson MIN | Owner | Tue Nov 25 6:16am CT |
| Started | WR | CeeDee Lamb DAL | Owner | Tue Nov 25 6:16am CT |
| Started | RB | Christian McCaffrey SF | Owner | Tue Nov 25 6:16am CT |
| Benched | RB | Christian McCaffrey SF | Owner | Tue Nov 25 6:12am CT |
| Benched | RB | David Montgomery DET | Owner | Tue Nov 25 6:12am CT |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Nov 25 6:12am CT |
| Benched | WR | Justin Jefferson MIN | Owner | Tue Nov 25 6:12am CT |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 25 6:12am CT |
| Benched | TE | Trey McBride ARI | Owner | Tue Nov 25 6:12am CT |
| Benched | K | Tyler Loop BAL | Owner | Tue Nov 25 6:12am CT |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 25 6:12am CT |
| Benched | QB | Drake Maye NE | Owner | Tue Nov 25 6:12am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Ladd McConkey LAC | Owner | Wed Nov 26 2:30pm CT |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 26 2:30pm CT |
| Benched | WR | A.J. Brown PHI | Owner | Wed Nov 26 2:29pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 2:29pm CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Sat Nov 29 9:15pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Sat Nov 29 9:15pm CT |
| Started | QB | Marcus Mariota WAS | Owner | Sat Nov 29 9:15pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Sat Nov 29 9:15pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Sat Nov 29 9:15pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 12:56am CT |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Wed Nov 26 12:56am CT |