

| Benched | RB | Quinshon Judkins CLE | Owner | Thu Nov 27 9:02am CT |
| Started | WR | Khalil Shakir BUF | Owner | Thu Nov 27 9:02am CT |
| Started | K | Jason Myers SEA | Owner | Wed Nov 26 11:23pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Wed Nov 26 7:35am CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 7:35am CT |
| Benched | QB | Sam Darnold SEA | Owner | Thu Nov 27 11:00am CT |
| Benched | K | Blake Grupe NO | Owner | Thu Nov 27 11:00am CT |
| Started | QB | Bo Nix DEN | Owner | Thu Nov 27 11:00am CT |
| Started | K | Daniel Carlson LV | Owner | Thu Nov 27 11:00am CT |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 11:01am CT |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Nov 25 11:01am CT |
| Benched | WR | Marquise Brown KC | Owner | Tue Nov 25 11:01am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 11:01am CT |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 11:01am CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 25 11:01am CT |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 25 3:21pm CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 3:21pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 8:07am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:07am CT |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 25 8:07am CT |
| Started | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 8:07am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 25 8:07am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 8:07am CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 2:01pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 2:01pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 5:28pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 5:28pm CT |
| Benched | WR | CeeDee Lamb DAL | Owner | Wed Nov 26 2:32pm CT |
| Started | WR | Rashee Rice KC | Owner | Wed Nov 26 2:32pm CT |
| Benched | WR | Rashee Rice KC | Owner | Wed Nov 26 2:32pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 2:32pm CT |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Wed Nov 26 2:32pm CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 2:32pm CT |
| Benched | WR | Greg Dortch ARI | Owner | Thu Nov 27 11:28am CT |
| Started | WR | Xavier Worthy KC | Owner | Thu Nov 27 11:28am CT |
| Benched | QB | Tyler Shough NO | Owner | Wed Nov 26 7:53pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 7:53pm CT |
| Benched | WR | Tre Tucker LV | Owner | Wed Nov 26 11:10am CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 11:10am CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Wed Nov 26 11:10am CT |
| Started | TE | Dalton Kincaid BUF | Owner | Wed Nov 26 11:10am CT |
| Benched | D/ST | Buffalo Bills BUF | Owner | Wed Nov 26 12:56pm CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Wed Nov 26 12:56pm CT |
| Started | D/ST | Arizona Cardinals ARI | Owner | Thu Nov 27 12:16am CT |
| Benched | WR | Chris Olave NO | Owner | Tue Nov 25 1:39pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 1:39pm CT |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Nov 25 1:39pm CT |
| Started | WR | Davante Adams LAR | Owner | Tue Nov 25 1:39pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 9:18pm CT |
| Started | QB | Tua Tagovailoa MIA | Owner | Wed Nov 26 9:18pm CT |
| Benched | RB | Devin Singletary NYG | Owner | Wed Nov 26 9:17pm CT |
| Benched | WR | Alec Pierce IND | Owner | Wed Nov 26 9:17pm CT |
| Started | RB | RJ Harvey DEN | Owner | Wed Nov 26 9:17pm CT |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 9:17pm CT |