

| Benched | K | Jake Bates DET | Owner | Wed Nov 26 11:35pm ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Wed Nov 26 11:35pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 7:52pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 25 7:52pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 7:27am ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 25 5:24pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 5:24pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 9:54am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 9:54am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 9:54am ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 9:54am ET |
| Benched | RB | Sean Tucker TB | Owner | Sat Nov 29 10:53pm ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Sat Nov 29 10:53pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Wed Nov 26 1:03pm ET |
| Benched | WR | Josh Downs IND | Owner | Wed Nov 26 1:03pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Wed Nov 26 1:03pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 1:03pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Wed Nov 26 5:20pm ET |
| Started | RB | Travis Etienne JAX | Owner | Wed Nov 26 5:20pm ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Wed Nov 26 5:20pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 5:20pm ET |
| Benched | WR | Michael Wilson ARI | Owner | Thu Nov 27 6:28am ET |
| Benched | TE | Dalton Kincaid BUF | Owner | Thu Nov 27 6:28am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 6:28am ET |
| Started | TE | Brenton Strange JAX | Owner | Thu Nov 27 6:28am ET |
| Benched | TE | Cade Otton TB | Owner | Wed Nov 26 10:10am ET |
| Started | TE | Dalton Kincaid BUF | Owner | Wed Nov 26 10:10am ET |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 4:30pm ET |
| Started | QB | Bo Nix DEN | Owner | Wed Nov 26 4:30pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Rachaad White TB | Owner | Sat Nov 29 11:52pm ET |
| Started | RB | Bucky Irving TB | Owner | Sat Nov 29 11:52pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 5:16pm ET |
| Benched | TE | George Kittle SF | Owner | Tue Nov 25 5:16pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 5:16pm ET |
| Started | WR | Stefon Diggs NE | Owner | Tue Nov 25 5:16pm ET |
| Benched | RB | Jerome Ford CLE | Owner | Sun Nov 30 8:19am ET |
| Started | RB | Ollie Gordon II MIA | Owner | Sun Nov 30 8:19am ET |
| Benched | QB | Jared Goff DET | Owner | Thu Nov 27 7:03am ET |
| Started | QB | Patrick Mahomes KC | Owner | Thu Nov 27 7:03am ET |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 25 10:37pm ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 25 10:37pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 10:37pm ET |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 25 10:37pm ET |
| Benched | WR | Xavier Hutchinson HOU | Owner | Thu Nov 27 10:44am ET |
| Benched | TE | Noah Fant CIN | Owner | Thu Nov 27 10:44am ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Thu Nov 27 10:44am ET |
| Started | TE | Evan Engram DEN | Owner | Thu Nov 27 10:44am ET |
| Benched | RB | Javonte Williams DAL | Owner | Thu Nov 27 9:25am ET |
| Started | RB | Ashton Jeanty LV | Owner | Thu Nov 27 9:25am ET |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 6:16pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 6:16pm ET |
| Started | QB | C.J. Stroud HOU | Owner | Tue Nov 25 6:16pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 6:16pm ET |