

| No starting lineup changes performed this week. |
| Benched | QB | Aaron Rodgers PIT | Owner | Tue Oct 28 12:25pm ET |
| Benched | TE | David Njoku CLE | Owner | Tue Oct 28 12:25pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Oct 28 12:25pm ET |
| Benched | QB | Jaxson Dart NYG | Owner | Tue Oct 28 9:27am ET |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 9:27am ET |
| Benched | WR | Tez Johnson TB | Owner | Tue Oct 28 9:27am ET |
| Benched | WR | Jaylin Noel HOU | Owner | Tue Oct 28 9:27am ET |
| Started | QB | Jared Goff DET | Owner | Tue Oct 28 9:27am ET |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 9:27am ET |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 9:27am ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 9:27am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Oct 28 5:31pm ET |
| Started | RB | Chuba Hubbard CAR | Owner | Tue Oct 28 5:31pm ET |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 5:31pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Oct 28 5:31pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 5:31pm ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Oct 28 5:31pm ET |
| Started | RB | Zach Charbonnet SEA | Owner | Tue Oct 28 5:31pm ET |
| Started | WR | D.J. Moore CHI | Owner | Tue Oct 28 5:31pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Oct 28 7:27am ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 7:27am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 7:26am ET |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Tue Oct 28 7:26am ET |
| Started | WR | George Pickens DAL | Owner | Tue Oct 28 7:26am ET |
| Started | D/ST | Chicago Bears CHI | Owner | Tue Oct 28 7:26am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |