

| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 11:25am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 11:49pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Wed Nov 26 11:49pm ET |
| Started | RB | Kyle Monangai CHI | Owner | Wed Nov 26 11:49pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 11:49pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Sat Nov 29 6:01pm ET |
| Benched | WR | Josh Downs IND | Owner | Sat Nov 29 6:01pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 6:01pm ET |
| Started | WR | Chimere Dike TEN | Owner | Sat Nov 29 6:01pm ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 27 12:51am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 9:46am ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 9:46am ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 25 12:31pm ET |
| Started | QB | Jacoby Brissett ARI | Owner | Tue Nov 25 12:31pm ET |
| Started | K | Cam Little JAX | Owner | Sun Nov 30 5:57am ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 4:16pm ET |
| Started | WR | Michael Wilson ARI | Owner | Wed Nov 26 4:16pm ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 1:04pm ET |
| Benched | WR | Mack Hollins NE | Owner | Wed Nov 26 1:04pm ET |
| Started | RB | Zach Charbonnet SEA | Owner | Wed Nov 26 1:04pm ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 1:04pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Wed Nov 26 9:38pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 9:38pm ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 9:20am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 9:20am ET |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 9:20am ET |
| Benched | WR | Xavier Worthy KC | Owner | Wed Nov 26 9:20am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 9:20am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 9:20am ET |
| No starting lineup changes performed this week. |
| Started | D/ST | New Orleans Saints NO | Owner | Sun Nov 30 11:26am ET |
| Benched | D/ST | Indianapolis Colts IND | Owner | Sun Nov 30 11:26am ET |
| Started | QB | Cam Ward TEN | Owner | Thu Nov 27 12:17am ET |
| Benched | QB | Jameis Winston NYG | Owner | Thu Nov 27 12:17am ET |
| Started | QB | Jameis Winston NYG | Owner | Thu Nov 27 12:15am ET |
| Benched | QB | Cam Ward TEN | Owner | Thu Nov 27 12:15am ET |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 11:56pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 11:56pm ET |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 25 11:56pm ET |
| Benched | TE | AJ Barner SEA | Owner | Tue Nov 25 11:56pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 11:56pm ET |
| Benched | QB | Geno Smith LV | Owner | Tue Nov 25 11:56pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Sun Nov 30 11:47am ET |
| Started | WR | Wan'Dale Robinson NYG | Owner | Sun Nov 30 11:47am ET |
| Benched | K | Chad Ryland ARI | Owner | Tue Nov 25 12:15pm ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 12:15pm ET |
| Benched | RB | Nick Chubb HOU | Owner | Thu Nov 27 12:52pm ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 12:52pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 26 8:37pm ET |
| Started | RB | Tyjae Spears TEN | Owner | Wed Nov 26 8:37pm ET |
| Benched | WR | Jayden Higgins HOU | Owner | Tue Nov 25 9:48pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:48pm ET |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Wed Nov 26 10:40pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 10:40pm ET |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 10:39pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 10:39pm ET |