

| Started | D/ST | Atlanta Falcons ATL | Owner | Thu Nov 27 12:32am ET |
| Benched | WR | DeVonta Smith PHI | Owner | Wed Nov 26 11:25pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Wed Nov 26 11:25pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 12:00am ET |
| Started | RB | Brian Robinson Jr. SF | Owner | Wed Nov 26 12:00am ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 26 11:53pm ET |
| Benched | WR | Christian Watson GB | Owner | Wed Nov 26 11:53pm ET |
| Benched | TE | Pat Freiermuth PIT | Owner | Wed Nov 26 11:53pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 11:53pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 11:53pm ET |
| Started | TE | Dalton Kincaid BUF | Owner | Wed Nov 26 11:53pm ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Thu Nov 27 3:41am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Nov 27 3:41am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Wed Nov 26 12:09am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 12:09am ET |
| Benched | TE | Mark Andrews BAL | Owner | Wed Nov 26 12:09am ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 12:09am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 12:09am ET |
| Started | TE | Cade Otton TB | Owner | Wed Nov 26 12:09am ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 25 7:19am ET |
| Started | QB | Jordan Love GB | Owner | Tue Nov 25 7:19am ET |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 6:12pm ET |
| Started | RB | Breece Hall NYJ | Owner | Wed Nov 26 6:12pm ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Wed Nov 26 6:12pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 6:12pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Justin Fields NYJ | Owner | Wed Nov 26 9:44am ET |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 26 9:44am ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 9:44am ET |
| Started | RB | Chuba Hubbard CAR | Owner | Wed Nov 26 9:44am ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 9:44am ET |
| Benched | TE | Isaiah Likely BAL | Owner | Wed Nov 26 9:44am ET |
| Benched | WR | Cedric Tillman CLE | Owner | Wed Nov 26 9:44am ET |
| Benched | WR | Tez Johnson TB | Owner | Wed Nov 26 9:44am ET |
| Benched | RB | Keaton Mitchell BAL | Owner | Wed Nov 26 9:44am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Wed Nov 26 9:44am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 26 6:48pm ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 6:48pm ET |
| Benched | D/ST | Dallas Cowboys DAL | Owner | Tue Nov 25 7:07am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 7:07am ET |
| Started | QB | Tyler Shough NO | Owner | Thu Nov 27 6:48am ET |
| Benched | D/ST | Detroit Lions DET | Owner | Thu Nov 27 6:39am ET |
| Started | K | Jake Bates DET | Owner | Thu Nov 27 6:39am ET |
| Started | D/ST | Indianapolis Colts IND | Owner | Thu Nov 27 6:39am ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 11:42am ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 25 11:30am ET |
| Benched | WR | Jalen Coker CAR | Owner | Tue Nov 25 11:30am ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 11:30am ET |
| Benched | QB | Baker Mayfield TB | Owner | Tue Nov 25 11:29am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 12:32am ET |
| Benched | QB | Jameis Winston NYG | Owner | Tue Nov 25 5:50pm ET |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 5:50pm ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 25 5:50pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 5:50pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 5:50pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 5:50pm ET |
| Benched | WR | Parker Washington JAX | Owner | Tue Nov 25 3:42pm ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 3:42pm ET |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 25 3:42pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 3:42pm ET |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 25 9:05am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 9:05am ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 25 9:05am ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 9:05am ET |