

| Add TB | QB | Patrick Mahomes KC | Commissioner | Tue Nov 25 3:56pm ET |
| Benched | WR | Chris Olave NO | Commissioner | Tue Nov 25 3:56pm ET |
| Started | RB | Bucky Irving TB | Commissioner | Tue Nov 25 3:56pm ET |
| Add TB | QB | Matthew Stafford LAR | Commissioner | Fri Nov 28 8:36pm ET |
| Started | RB | Kyle Monangai CHI | Commissioner | Wed Nov 26 6:54am ET |
| Benched | WR | Darnell Mooney ATL | Commissioner | Wed Nov 26 6:54am ET |
| Started | D/ST | Los Angeles Chargers LAC | Commissioner | Wed Nov 26 6:34am ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Commissioner | Wed Nov 26 6:34am ET |
| Started | WR | Christian Watson GB | Commissioner | Tue Nov 25 3:59pm ET |
| Benched | RB | Kyle Monangai CHI | Commissioner | Tue Nov 25 3:59pm ET |
| Started | WR | Ja'Marr Chase CIN | Commissioner | Tue Nov 25 3:57pm ET |
| Benched | WR | Alec Pierce IND | Commissioner | Tue Nov 25 3:57pm ET |
| Started | D/ST | Pittsburgh Steelers PIT | Commissioner | Tue Nov 25 10:11am ET |
| Benched | TE | Juwan Johnson NO | Owner | Thu Nov 27 11:38am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 11:38am ET |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 11:37am ET |
| Started | TE | Juwan Johnson NO | Owner | Thu Nov 27 11:37am ET |
| Started | TE | Brenton Strange JAX | Owner | Wed Nov 26 9:08am ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 8:23pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 8:23pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 5:24pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Thu Nov 27 5:24pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 7:40pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 25 7:40pm ET |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 7:36pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 7:36pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 25 7:36pm ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 7:36pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 7:36pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 7:36pm ET |
| Benched | QB | Jared Goff DET | Owner | Thu Nov 27 11:41am ET |
| Drop TB | QB | Jared Goff DET | Owner | Thu Nov 27 11:41am ET |
| Started | QB | Dak Prescott DAL | Owner | Thu Nov 27 11:41am ET |
| Add TB | QB | Dak Prescott DAL | Owner | Thu Nov 27 11:41am ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 27 11:24am ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 27 11:24am ET |
| Benched | WR | D.K. Metcalf PIT | Owner | Thu Nov 27 11:24am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Thu Nov 27 11:24am ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 8:22am ET |
| Started | WR | Ricky Pearsall SF | Owner | Wed Nov 26 8:22am ET |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 8:27am ET |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Tue Nov 25 8:27am ET |
| Started | TE | Travis Kelce KC | Owner | Tue Nov 25 8:27am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 8:27am ET |
| Benched | WR | Kayshon Boutte NE | Owner | Thu Nov 27 1:11pm ET |
| Benched | TE | AJ Barner SEA | Owner | Thu Nov 27 1:11pm ET |
| Started | RB | Kimani Vidal LAC | Owner | Thu Nov 27 1:11pm ET |
| Started | WR | Troy Franklin DEN | Owner | Thu Nov 27 1:11pm ET |
| Started | RB | Javonte Williams DAL | Owner | Tue Nov 25 12:04pm ET |
| Benched | WR | Tez Johnson TB | Owner | Tue Nov 25 12:04pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 12:04pm ET |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 25 12:04pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 12:04pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 12:04pm ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 25 12:04pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 12:04pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 25 12:04pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 25 12:04pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 4:39pm ET |
| Started | RB | Tyler Allgeier ATL | Owner | Wed Nov 26 4:39pm ET |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 4:39pm ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 4:39pm ET |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 25 10:31am ET |
| Started | RB | Rachaad White TB | Owner | Tue Nov 25 10:31am ET |
| Add TB | QB | Justin Herbert LAC | Owner | Tue Nov 25 10:31am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 10:31am ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 25 10:31am ET |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 10:31am ET |
| Drop TB | QB | Lamar Jackson BAL | Owner | Tue Nov 25 10:31am ET |
| Benched | QB | Lamar Jackson BAL | Owner | Tue Nov 25 10:31am ET |
| Benched | RB | Aaron Jones MIN | Owner | Thu Nov 27 8:45am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 8:45am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 5:42pm ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 5:42pm ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 12:49pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 12:49pm ET |
| Benched | QB | Baker Mayfield TB | Owner | Wed Nov 26 7:41pm ET |
| Benched | WR | Sterling Shepard TB | Owner | Wed Nov 26 7:41pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 7:41pm ET |
| Started | WR | Josh Downs IND | Owner | Wed Nov 26 7:41pm ET |
| Benched | D/ST | New England Patriots NE | Owner | Sun Nov 30 9:32am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Sun Nov 30 9:32am ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 7:03pm ET |
| Started | WR | Xavier Worthy KC | Owner | Wed Nov 26 7:03pm ET |
| Started | K | Seattle Seahawks SEA | Owner | Tue Nov 25 11:31pm ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 8:57am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Tue Nov 25 8:57am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 8:57am ET |
| Started | D/ST | New England Patriots NE | Owner | Tue Nov 25 8:57am ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Thu Nov 27 4:33pm ET |
| Add TB | TE | George Kittle SF | Owner | Thu Nov 27 12:49pm ET |
| Drop TB | WR | Christian Watson GB | Owner | Thu Nov 27 12:49pm ET |
| Started | WR | Christian Watson GB | Owner | Thu Nov 27 12:49pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Thu Nov 27 12:49pm ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 8:36pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Wed Nov 26 8:36pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 3:31pm ET |
| Benched | QB | Brock Purdy SF | Owner | Tue Nov 25 3:31pm ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 25 3:31pm ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Tue Nov 25 3:31pm ET |
| Started | WR | Nico Collins HOU | Owner | Tue Nov 25 3:30pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 25 3:30pm ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 3:30pm ET |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 25 3:30pm ET |
| Benched | WR | Chris Olave NO | Owner | Thu Nov 27 6:17am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Thu Nov 27 6:17am ET |
| Benched | WR | Jordan Addison MIN | Owner | Fri Nov 28 8:31pm ET |
| Started | WR | Terry McLaurin WAS | Owner | Fri Nov 28 8:31pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Thu Nov 27 3:19pm ET |
| Started | RB | TreVeyon Henderson NE | Owner | Thu Nov 27 3:19pm ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Thu Nov 27 3:17pm ET |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 3:17pm ET |
| No starting lineup changes performed this week. |