

| Benched | RB | Saquon Barkley PHI | Commissioner | Tue Oct 28 8:46pm ET |
| Benched | WR | Emeka Egbuka TB | Commissioner | Tue Oct 28 8:46pm ET |
| Benched | TE | Dalton Schultz HOU | Commissioner | Tue Oct 28 8:46pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Commissioner | Tue Oct 28 8:46pm ET |
| Started | WR | Jaxon Smith-Njigba SEA | Commissioner | Tue Oct 28 8:46pm ET |
| Started | TE | Trey McBride ARI | Commissioner | Tue Oct 28 8:46pm ET |
| Benched | RB | Jordan Mason MIN | Commissioner | Tue Oct 28 8:57pm ET |
| Started | WR | Drake London ATL | Commissioner | Tue Oct 28 8:57pm ET |
| Benched | QB | Baker Mayfield TB | Commissioner | Tue Oct 28 7:46am ET |
| Drop TB | QB | Baker Mayfield TB | Commissioner | Tue Oct 28 7:46am ET |
| Benched | RB | Isiah Pacheco KC | Commissioner | Tue Oct 28 7:46am ET |
| Started | QB | Lamar Jackson BAL | Commissioner | Tue Oct 28 7:46am ET |
| Started | RB | Kenneth Walker III SEA | Commissioner | Tue Oct 28 7:46am ET |
| Started | WR | Jaxon Smith-Njigba SEA | Commissioner | Tue Oct 28 7:46am ET |
| No starting lineup changes performed this week. |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Oct 28 2:00pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 2:00pm ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Oct 28 2:00pm ET |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 2:00pm ET |
| Benched | QB | Justin Fields NYJ | Owner | Tue Oct 28 8:00pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Oct 28 8:00pm ET |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 8:00pm ET |
| Started | RB | Jacory Croskey-Merritt WAS | Owner | Tue Oct 28 8:00pm ET |
| Add TB | QB | Kyler Murray ARI | Owner | Tue Oct 28 8:00pm ET |
| Started | QB | Kyler Murray ARI | Owner | Tue Oct 28 8:00pm ET |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Oct 28 8:00pm ET |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 8:00pm ET |
| Benched | RB | Cam Skattebo NYG | Owner | Tue Oct 28 8:00pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 8:00pm ET |
| Drop TB | QB | Justin Fields NYJ | Owner | Tue Oct 28 8:00pm ET |
| Started | WR | Jameson Williams DET | Owner | Tue Oct 28 8:00pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Oct 28 4:09pm ET |
| Benched | RB | Cam Skattebo NYG | Owner | Tue Oct 28 4:09pm ET |
| Started | RB | Travis Etienne JAX | Owner | Tue Oct 28 4:09pm ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Oct 28 4:09pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Aaron Rodgers PIT | Owner | Tue Oct 28 10:57am ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Oct 28 10:57am ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Oct 28 10:57am ET |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Tue Oct 28 10:57am ET |
| Started | QB | Sam Darnold SEA | Owner | Tue Oct 28 10:57am ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 10:57am ET |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 10:57am ET |
| Started | D/ST | Seattle Seahawks SEA | Owner | Tue Oct 28 10:57am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | Rome Odunze CHI | Owner | Tue Oct 28 7:41pm ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Oct 28 7:41pm ET |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 9:21am ET |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Oct 28 9:21am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Oct 28 9:21am ET |
| Started | D/ST | Houston Texans HOU | Owner | Tue Oct 28 9:21am ET |
| No starting lineup changes performed this week. |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Oct 28 8:44am ET |
| Started | RB | Kimani Vidal LAC | Owner | Tue Oct 28 8:44am ET |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Oct 28 8:44am ET |
| Benched | D/ST | Indianapolis Colts IND | Owner | Tue Oct 28 8:44am ET |
| Benched | WR | Keenan Allen LAC | Owner | Tue Oct 28 8:44am ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Oct 28 8:44am ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 8:16am ET |
| Started | QB | Joe Flacco CIN | Owner | Tue Oct 28 8:16am ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Oct 28 8:16am ET |
| Drop TB | QB | Jalen Hurts PHI | Owner | Tue Oct 28 8:16am ET |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 8:16am ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Oct 28 12:01pm ET |
| Benched | RB | Isiah Pacheco KC | Owner | Tue Oct 28 12:01pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Oct 28 12:01pm ET |
| Started | WR | Christian Watson GB | Owner | Tue Oct 28 12:01pm ET |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 12:00pm ET |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Tue Oct 28 12:00pm ET |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 12:00pm ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Oct 28 12:00pm ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | D.J. Moore CHI | Owner | Tue Oct 28 9:35pm ET |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 9:35pm ET |