

| Benched | RB | Quinshon Judkins CLE | Owner | Thu Nov 20 6:47pm ET |
| Started | RB | Aaron Jones MIN | Owner | Thu Nov 20 6:47pm ET |
| Benched | RB | Aaron Jones MIN | Owner | Tue Nov 18 12:44pm ET |
| Started | RB | Jonathan Taylor IND | Owner | Tue Nov 18 12:44pm ET |
| No starting lineup changes performed this week. |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 18 10:12pm ET |
| Started | RB | David Montgomery DET | Owner | Tue Nov 18 10:12pm ET |
| Started | K | Jake Elliott PHI | Owner | Thu Nov 20 7:38am ET |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 18 10:30pm ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 18 10:30pm ET |
| Benched | WR | Drake London ATL | Owner | Wed Nov 19 9:31pm ET |
| Started | WR | Rashid Shaheed SEA | Owner | Wed Nov 19 9:31pm ET |
| Benched | RB | Devon Achane MIA | Owner | Thu Nov 20 2:40am ET |
| Started | WR | Chris Olave NO | Owner | Thu Nov 20 2:40am ET |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Thu Nov 20 2:39am ET |
| Benched | K | Cameron Dicker LAC | Owner | Thu Nov 20 7:24pm ET |
| Started | K | Nick Folk NYJ | Owner | Thu Nov 20 7:24pm ET |
| Benched | WR | Ladd McConkey LAC | Owner | Tue Nov 18 7:45pm ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 18 7:45pm ET |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Nov 18 7:45pm ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Tue Nov 18 7:45pm ET |
| Started | TE | Tyler Warren IND | Owner | Tue Nov 18 7:45pm ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 18 7:45pm ET |
| Started | K | Chad Ryland ARI | Owner | Thu Nov 20 8:17am ET |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 19 10:19pm ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Wed Nov 19 10:19pm ET |
| Benched | WR | Keenan Allen LAC | Owner | Tue Nov 18 7:52am ET |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 18 7:52am ET |
| Benched | TE | Cade Otton TB | Owner | Thu Nov 20 8:20am ET |
| Started | TE | Juwan Johnson NO | Owner | Thu Nov 20 8:20am ET |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 18 10:43am ET |
| Started | RB | Zach Charbonnet SEA | Owner | Tue Nov 18 10:43am ET |
| Benched | RB | Emari Demercado ARI | Owner | Fri Nov 21 12:27am ET |
| Started | RB | Jordan Mason MIN | Owner | Fri Nov 21 12:27am ET |
| Benched | WR | Courtland Sutton DEN | Owner | Wed Nov 19 8:09pm ET |
| Benched | K | Matt Prater BUF | Owner | Wed Nov 19 8:09pm ET |
| Started | TE | Kyle Pitts ATL | Owner | Wed Nov 19 8:09pm ET |
| Started | K | Tyler Loop BAL | Owner | Wed Nov 19 8:09pm ET |
| No starting lineup changes performed this week. |
| Started | RB | Emanuel Wilson GB | Owner | Thu Nov 20 7:01pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Thu Nov 20 7:01pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 20 7:01pm ET |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 20 7:01pm ET |
| Started | WR | Darnell Mooney ATL | Owner | Tue Nov 18 11:02am ET |
| Started | RB | Alvin Kamara NO | Owner | Tue Nov 18 11:02am ET |
| Started | QB | Daniel Jones IND | Owner | Tue Nov 18 11:02am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 11:02am ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Nov 18 11:02am ET |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 18 11:02am ET |