

| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 20 6:39pm ET |
| Benched | WR | Keenan Allen LAC | Owner | Tue Nov 18 2:16pm ET |
| Started | WR | Davante Adams LAR | Owner | Tue Nov 18 2:16pm ET |
| Started | QB | Matthew Stafford LAR | Owner | Thu Nov 20 1:26pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Thu Nov 20 1:26pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Thu Nov 20 1:26pm ET |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 20 1:26pm ET |
| Started | WR | Michael Wilson ARI | Owner | Thu Nov 20 12:10am ET |
| Benched | WR | Jayden Higgins HOU | Owner | Thu Nov 20 12:10am ET |
| Started | K | Tyler Loop BAL | Owner | Thu Nov 20 12:10am ET |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 18 11:48am ET |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 18 11:48am ET |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 18 11:48am ET |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Nov 18 11:48am ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 18 7:14am ET |
| Started | RB | Rachaad White TB | Owner | Tue Nov 18 7:14am ET |
| Benched | K | Wil Lutz DEN | Owner | Tue Nov 18 7:14am ET |
| Benched | WR | Courtland Sutton DEN | Owner | Tue Nov 18 7:14am ET |
| Benched | RB | Devon Achane MIA | Owner | Tue Nov 18 7:14am ET |
| Benched | RB | Emari Demercado ARI | Owner | Wed Nov 19 9:50pm ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Wed Nov 19 9:50pm ET |
| Started | RB | Jonathan Taylor IND | Owner | Wed Nov 19 9:50pm ET |
| Started | WR | Christian Watson GB | Owner | Wed Nov 19 9:50pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Christian Kirk HOU | Owner | Thu Nov 20 4:16pm ET |
| Started | WR | Khalil Shakir BUF | Owner | Thu Nov 20 4:16pm ET |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Nov 18 3:49pm ET |
| Benched | WR | Khalil Shakir BUF | Owner | Tue Nov 18 3:49pm ET |
| Started | RB | Alvin Kamara NO | Owner | Tue Nov 18 3:49pm ET |
| Started | WR | Christian Kirk HOU | Owner | Tue Nov 18 3:49pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 20 4:58am ET |
| Started | RB | Kenneth Gainwell PIT | Owner | Thu Nov 20 4:58am ET |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 18 10:05am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 18 10:05am ET |
| Benched | RB | Josh Jacobs GB | Owner | Wed Nov 19 10:48pm ET |
| Started | RB | Devin Singletary NYG | Owner | Wed Nov 19 10:48pm ET |
| Started | K | Chris Boswell PIT | Owner | Thu Nov 20 12:04am ET |
| Started | RB | Zonovan Knight ARI | Owner | Tue Nov 18 8:25am ET |
| Started | RB | David Montgomery DET | Owner | Tue Nov 18 8:25am ET |
| Started | WR | Jerry Jeudy CLE | Owner | Tue Nov 18 8:25am ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 18 7:32am ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 18 7:32am ET |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 18 7:32am ET |
| Benched | WR | Drake London ATL | Owner | Tue Nov 18 4:18pm ET |
| Benched | WR | Ladd McConkey LAC | Owner | Tue Nov 18 4:18pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 18 4:18pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 18 4:18pm ET |
| Started | QB | Shedeur Sanders CLE | Owner | Thu Nov 20 12:34am ET |
| Benched | QB | Marcus Mariota WAS | Owner | Tue Nov 18 3:56pm ET |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 18 3:56pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Tue Nov 18 3:56pm ET |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Nov 18 3:56pm ET |
| Started | WR | Chris Olave NO | Owner | Tue Nov 18 3:56pm ET |
| Started | TE | Tyler Warren IND | Owner | Tue Nov 18 3:56pm ET |
| Benched | RB | Zach Charbonnet SEA | Owner | Tue Nov 18 8:15am ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 18 8:15am ET |
| No starting lineup changes performed this week. |