

| Benched | QB | J.J. McCarthy MIN | Owner | Wed Nov 26 1:45pm ET |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Nov 26 1:45pm ET |
| Started | QB | Sam Darnold SEA | Owner | Wed Nov 26 1:45pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Wed Nov 26 1:45pm ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 9:43am ET |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 9:43am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Quinshon Judkins CLE | Owner | Thu Nov 27 1:00pm ET |
| Started | RB | Breece Hall NYJ | Owner | Thu Nov 27 1:00pm ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 1:00pm ET |
| Benched | WR | Keon Coleman BUF | Owner | Thu Nov 27 9:56pm ET |
| Started | RB | Blake Corum LAR | Owner | Thu Nov 27 9:56pm ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 12:03pm ET |
| Started | QB | Dak Prescott DAL | Owner | Wed Nov 26 12:03pm ET |
| Benched | RB | Blake Corum LAR | Owner | Wed Nov 26 12:03pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 12:03pm ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 12:03pm ET |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 26 12:03pm ET |
| Benched | RB | D'Andre Swift CHI | Owner | Thu Nov 27 1:59am ET |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 1:59am ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 11:43pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Wed Nov 26 11:43pm ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 11:43pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 11:43pm ET |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 25 8:10am ET |
| Benched | RB | Sean Tucker TB | Owner | Tue Nov 25 8:10am ET |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 8:10am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 8:10am ET |
| Benched | WR | Stefon Diggs NE | Owner | Thu Nov 27 1:33am ET |
| Started | RB | Josh Jacobs GB | Owner | Thu Nov 27 1:33am ET |
| Benched | TE | Hunter Henry NE | Owner | Thu Nov 27 5:06am ET |
| Started | RB | Kareem Hunt KC | Owner | Thu Nov 27 5:06am ET |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 25 9:10pm ET |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Nov 25 9:10pm ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 9:10pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 9:10pm ET |
| Started | TE | Brenton Strange JAX | Owner | Sun Nov 30 11:58am ET |
| Benched | RB | Woody Marks HOU | Owner | Thu Nov 27 12:43pm ET |
| Started | RB | David Montgomery DET | Owner | Thu Nov 27 12:43pm ET |