

| Benched | K | Chase McLaughlin TB | Owner | Tue Nov 25 11:40am ET |
| Started | K | Cameron Dicker LAC | Owner | Tue Nov 25 11:40am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 11:40am ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 25 11:40am ET |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Thu Nov 27 12:39am ET |
| Started | D/ST | Tennessee Titans TEN | Owner | Thu Nov 27 12:39am ET |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 11:12pm ET |
| Started | WR | Chris Godwin TB | Owner | Tue Nov 25 11:12pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Nov 25 5:04pm ET |
| Benched | TE | Isaiah Likely BAL | Owner | Tue Nov 25 5:04pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 5:04pm ET |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 25 5:04pm ET |
| Benched | D/ST | Green Bay Packers GB | Owner | Thu Nov 27 7:15am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Thu Nov 27 7:15am ET |
| Benched | WR | Chris Olave NO | Owner | Tue Nov 25 9:57am ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 9:57am ET |
| Benched | WR | Greg Dortch ARI | Owner | Tue Nov 25 9:56am ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 9:56am ET |
| Started | RB | Devon Achane MIA | Owner | Tue Nov 25 9:56am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 9:56am ET |
| Benched | RB | Jordan Mason MIN | Owner | Sat Nov 29 5:36pm ET |
| Started | RB | Sean Tucker TB | Owner | Sat Nov 29 5:36pm ET |
| Benched | RB | Sean Tucker TB | Owner | Sat Nov 29 5:36pm ET |
| Started | RB | Jordan Mason MIN | Owner | Sat Nov 29 5:36pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Tue Nov 25 5:16pm ET |
| Benched | WR | Khalil Shakir BUF | Owner | Tue Nov 25 5:16pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 5:16pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 5:16pm ET |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 25 10:23am ET |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 25 10:23am ET |
| Benched | RB | Woody Marks HOU | Owner | Wed Nov 26 10:55am ET |
| Started | RB | Devin Neal NO | Owner | Wed Nov 26 10:55am ET |
| No starting lineup changes performed this week. |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 12:41am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Wed Nov 26 12:41am ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 27 12:46pm ET |
| Benched | QB | Daniel Jones IND | Owner | Wed Nov 26 6:37pm ET |
| Benched | RB | David Montgomery DET | Owner | Wed Nov 26 6:37pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 6:37pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 6:37pm ET |
| Benched | WR | Michael Wilson ARI | Owner | Wed Nov 26 5:04pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 5:04pm ET |
| Benched | D/ST | Baltimore Ravens BAL | Owner | Wed Nov 26 3:49pm ET |
| Started | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 26 3:49pm ET |
| Benched | RB | Isaiah Davis NYJ | Owner | Tue Nov 25 2:00pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 2:00pm ET |
| Started | RB | Chris Rodriguez Jr. WAS | Owner | Tue Nov 25 2:00pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 2:00pm ET |