

| Benched | TE | Colston Loveland CHI | Owner | Wed Nov 26 10:33pm CT |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 26 10:33pm CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 6:52pm CT |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 6:52pm CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 6:52pm CT |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 25 6:52pm CT |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 9:39am CT |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 9:39am CT |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 10:49am CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 10:49am CT |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 6:55am CT |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 6:55am CT |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 5:00pm CT |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 5:00pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Ricky Pearsall SF | Owner | Sat Nov 29 10:05am CT |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 10:05am CT |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 11:18am CT |
| Started | WR | Ricky Pearsall SF | Owner | Wed Nov 26 11:18am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 8:53am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 8:53am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 8:52am CT |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 8:52am CT |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 5:57pm CT |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 26 5:57pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 5:57pm CT |
| Started | TE | Brenton Strange JAX | Owner | Wed Nov 26 5:57pm CT |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 4:44pm CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 4:44pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 4:44pm CT |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 4:44pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 27 4:50am CT |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 4:50am CT |
| Benched | D/ST | Cleveland Browns CLE | Owner | Thu Nov 27 4:50am CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 4:50am CT |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 4:50am CT |
| Started | D/ST | New England Patriots NE | Owner | Thu Nov 27 4:50am CT |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 7:15pm CT |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 7:15pm CT |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 5:51pm CT |
| Benched | WR | Jayden Higgins HOU | Owner | Wed Nov 26 5:51pm CT |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 5:13pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 5:13pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 5:13pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 5:13pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 5:13pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 5:13pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 26 3:11pm CT |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 3:11pm CT |
| Benched | QB | Joe Burrow CIN | Owner | Wed Nov 26 3:09pm CT |
| Benched | TE | Taysom Hill NO | Owner | Wed Nov 26 3:09pm CT |
| Started | QB | Sam Darnold SEA | Owner | Wed Nov 26 3:09pm CT |
| Started | TE | Ja'Tavion Sanders CAR | Owner | Wed Nov 26 3:09pm CT |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 25 11:47pm CT |
| Started | QB | Joe Burrow CIN | Owner | Tue Nov 25 11:47pm CT |