

| Benched | TE | Colston Loveland CHI | Owner | Wed Nov 26 11:33pm ET |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 26 11:33pm ET |
| Benched | WR | Jameson Williams DET | Owner | Tue Nov 25 7:52pm ET |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 25 7:52pm ET |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:52pm ET |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 25 7:52pm ET |
| Started | K | Cameron Dicker LAC | Owner | Thu Nov 27 10:39am ET |
| Started | D/ST | Denver Broncos DEN | Owner | Thu Nov 27 10:39am ET |
| Benched | RB | Devin Singletary NYG | Owner | Tue Nov 25 11:49am ET |
| Started | RB | Devin Neal NO | Owner | Tue Nov 25 11:49am ET |
| Benched | RB | Alvin Kamara NO | Owner | Thu Nov 27 7:55am ET |
| Started | WR | Darnell Mooney ATL | Owner | Thu Nov 27 7:55am ET |
| Benched | RB | Rachaad White TB | Owner | Wed Nov 26 6:00pm ET |
| Started | RB | Bucky Irving TB | Owner | Wed Nov 26 6:00pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Ricky Pearsall SF | Owner | Sat Nov 29 11:05am ET |
| Started | RB | Kimani Vidal LAC | Owner | Sat Nov 29 11:05am ET |
| Benched | TE | Juwan Johnson NO | Owner | Wed Nov 26 12:18pm ET |
| Started | WR | Ricky Pearsall SF | Owner | Wed Nov 26 12:18pm ET |
| Benched | WR | Ricky Pearsall SF | Owner | Tue Nov 25 9:53am ET |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 25 9:53am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 9:52am ET |
| Started | WR | Xavier Worthy KC | Owner | Tue Nov 25 9:52am ET |
| Benched | RB | Sean Tucker TB | Owner | Wed Nov 26 6:57pm ET |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 26 6:57pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Wed Nov 26 6:57pm ET |
| Started | TE | Brenton Strange JAX | Owner | Wed Nov 26 6:57pm ET |
| Benched | WR | Romeo Doubs GB | Owner | Tue Nov 25 5:44pm ET |
| Benched | WR | Alec Pierce IND | Owner | Tue Nov 25 5:44pm ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 25 5:44pm ET |
| Started | WR | Parker Washington JAX | Owner | Tue Nov 25 5:44pm ET |
| Benched | RB | Kareem Hunt KC | Owner | Thu Nov 27 5:50am ET |
| Benched | RB | David Montgomery DET | Owner | Thu Nov 27 5:50am ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Thu Nov 27 5:50am ET |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 5:50am ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 5:50am ET |
| Started | D/ST | New England Patriots NE | Owner | Thu Nov 27 5:50am ET |
| Started | QB | Justin Herbert LAC | Owner | Wed Nov 26 8:15pm ET |
| Benched | QB | Jacoby Brissett ARI | Owner | Wed Nov 26 8:15pm ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 6:51pm ET |
| Benched | WR | Jayden Higgins HOU | Owner | Wed Nov 26 6:51pm ET |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 25 6:13pm ET |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 25 6:13pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 6:13pm ET |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 25 6:13pm ET |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 25 6:13pm ET |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 25 6:13pm ET |
| No starting lineup changes performed this week. |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 26 4:11pm ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 4:11pm ET |
| Benched | QB | Joe Burrow CIN | Owner | Wed Nov 26 4:09pm ET |
| Benched | TE | Taysom Hill NO | Owner | Wed Nov 26 4:09pm ET |
| Started | QB | Sam Darnold SEA | Owner | Wed Nov 26 4:09pm ET |
| Started | TE | Ja'Tavion Sanders CAR | Owner | Wed Nov 26 4:09pm ET |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 26 12:47am ET |
| Started | QB | Joe Burrow CIN | Owner | Wed Nov 26 12:47am ET |