

| Benched | RB | Tyjae Spears TEN | Owner | Thu Nov 27 12:57pm ET |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 27 12:57pm ET |
| Benched | WR | Van Jefferson TEN | Owner | Thu Nov 27 12:57pm ET |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 12:57pm ET |
| Started | RB | Devin Neal NO | Owner | Thu Nov 27 12:57pm ET |
| Started | WR | Deebo Samuel WAS | Owner | Thu Nov 27 12:57pm ET |
| Benched | QB | Kirk Cousins ATL | Owner | Thu Nov 27 10:52am ET |
| Started | QB | Justin Herbert LAC | Owner | Thu Nov 27 10:52am ET |
| Benched | K | Tyler Loop BAL | Owner | Wed Nov 26 8:12pm ET |
| Started | WR | Kayshon Boutte NE | Owner | Wed Nov 26 8:12pm ET |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 8:12pm ET |
| No starting lineup changes performed this week. |
| Benched | WR | Mack Hollins NE | Owner | Thu Nov 27 8:53am ET |
| Started | WR | Devaughn Vele NO | Owner | Thu Nov 27 8:53am ET |
| Started | K | Harrison Mevis LAR | Owner | Thu Nov 27 8:53am ET |
| Started | D/ST | Miami Dolphins MIA | Owner | Thu Nov 27 8:53am ET |
| Benched | RB | Nick Chubb HOU | Owner | Wed Nov 26 10:49pm ET |
| Benched | WR | Josh Palmer BUF | Owner | Wed Nov 26 10:49pm ET |
| Started | WR | Tyler Lockett LV | Owner | Wed Nov 26 10:49pm ET |
| Started | WR | Malik Washington MIA | Owner | Wed Nov 26 10:49pm ET |
| Benched | RB | Quinshon Judkins CLE | Owner | Wed Nov 26 5:55pm ET |
| Started | RB | Rico Dowdle CAR | Owner | Wed Nov 26 5:55pm ET |
| Benched | QB | Brock Purdy SF | Owner | Wed Nov 26 5:54pm ET |
| Benched | RB | Rico Dowdle CAR | Owner | Wed Nov 26 5:54pm ET |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Nov 26 5:54pm ET |
| Started | RB | Breece Hall NYJ | Owner | Wed Nov 26 5:54pm ET |
| Benched | QB | Davis Mills HOU | Owner | Wed Nov 26 12:37am ET |
| Benched | WR | Xavier Worthy KC | Owner | Wed Nov 26 12:37am ET |
| Benched | D/ST | New Orleans Saints NO | Owner | Wed Nov 26 12:37am ET |
| Started | QB | Jaxson Dart NYG | Owner | Wed Nov 26 12:37am ET |
| Started | WR | D.J. Moore CHI | Owner | Wed Nov 26 12:37am ET |
| Started | D/ST | Los Angeles Chargers LAC | Owner | Wed Nov 26 12:37am ET |
| Benched | QB | Joe Flacco CIN | Owner | Thu Nov 27 6:02pm ET |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 6:02pm ET |
| Benched | RB | Tony Pollard TEN | Owner | Wed Nov 26 8:10am ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Wed Nov 26 8:10am ET |
| Started | RB | Devon Achane MIA | Owner | Wed Nov 26 8:10am ET |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 8:10am ET |
| Started | QB | Jordan Love GB | Owner | Thu Nov 27 12:30pm ET |
| Benched | QB | Daniel Jones IND | Owner | Thu Nov 27 12:30pm ET |
| Started | WR | Christian Watson GB | Owner | Wed Nov 26 6:13pm ET |
| Benched | WR | Drake London ATL | Owner | Wed Nov 26 6:13pm ET |
| Started | WR | Troy Franklin DEN | Owner | Tue Nov 25 3:42pm ET |
| Benched | WR | Christian Watson GB | Owner | Tue Nov 25 3:42pm ET |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 25 3:42pm ET |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Tue Nov 25 3:42pm ET |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 25 3:42pm ET |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 3:42pm ET |
| Started | WR | Drake London ATL | Owner | Tue Nov 25 3:41pm ET |
| Benched | WR | Jordan Addison MIN | Owner | Tue Nov 25 3:41pm ET |
| Started | D/ST | San Francisco 49ers SF | Owner | Fri Nov 28 7:29pm ET |
| Benched | D/ST | Atlanta Falcons ATL | Owner | Fri Nov 28 7:29pm ET |
| Started | WR | Keenan Allen LAC | Owner | Wed Nov 26 10:38pm ET |
| Benched | TE | Theo Johnson NYG | Owner | Wed Nov 26 10:38pm ET |
| Started | D/ST | Atlanta Falcons ATL | Owner | Wed Nov 26 10:37pm ET |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 10:37pm ET |
| Started | RB | Derrick Henry BAL | Owner | Wed Nov 26 10:37pm ET |
| Started | QB | Josh Allen BUF | Owner | Wed Nov 26 10:37pm ET |
| Benched | D/ST | Cleveland Browns CLE | Owner | Wed Nov 26 10:37pm ET |
| Benched | RB | Alvin Kamara NO | Owner | Wed Nov 26 10:37pm ET |
| Benched | RB | Chris Brooks GB | Owner | Wed Nov 26 10:37pm ET |
| Benched | QB | Drake Maye NE | Owner | Wed Nov 26 10:37pm ET |
| Benched | WR | Tee Higgins CIN | Owner | Wed Nov 26 3:20pm ET |
| Benched | TE | AJ Barner SEA | Owner | Wed Nov 26 3:20pm ET |
| Started | WR | Courtland Sutton DEN | Owner | Wed Nov 26 3:20pm ET |
| Started | TE | Zach Ertz WAS | Owner | Wed Nov 26 3:20pm ET |
| Benched | RB | Emanuel Wilson GB | Owner | Thu Nov 27 8:38am ET |
| Started | RB | David Montgomery DET | Owner | Thu Nov 27 8:38am ET |
| Benched | WR | Andrei Iosivas CIN | Owner | Tue Nov 25 9:54am ET |
| Benched | WR | Tre Tucker LV | Owner | Tue Nov 25 9:54am ET |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 9:54am ET |
| Started | WR | John Metchie III NYJ | Owner | Tue Nov 25 9:54am ET |
| Benched | QB | Bryce Young CAR | Owner | Tue Nov 25 11:10pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 25 11:10pm ET |
| Benched | WR | Sterling Shepard TB | Owner | Tue Nov 25 11:10pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 25 11:10pm ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 25 11:10pm ET |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 25 11:10pm ET |