

| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 11:22am ET |
| Benched | RB | Ollie Gordon II MIA | Owner | Tue Nov 4 11:22am ET |
| Benched | WR | Jakobi Meyers JAX | Owner | Tue Nov 4 11:22am ET |
| Benched | D/ST | San Francisco 49ers SF | Owner | Tue Nov 4 11:22am ET |
| Started | QB | Matthew Stafford LAR | Owner | Tue Nov 4 11:22am ET |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 11:22am ET |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 4 11:22am ET |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 4 11:22am ET |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | D/ST | New York Giants NYG | Owner | Tue Nov 4 10:05am ET |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 4 10:05am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 10:01am ET |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 10:01am ET |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 10:01am ET |
| Started | WR | Luther Burden III CHI | Owner | Tue Nov 4 10:01am ET |
| Started | WR | Xavier Legette CAR | Owner | Tue Nov 4 10:01am ET |
| Started | WR | Dont'e Thornton Jr. LV | Owner | Tue Nov 4 10:01am ET |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 4 9:46pm ET |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 9:46pm ET |
| Benched | QB | Jared Goff DET | Owner | Tue Nov 4 3:15pm ET |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 3:15pm ET |
| Benched | TE | Kyle Pitts ATL | Owner | Tue Nov 4 3:15pm ET |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 4 3:15pm ET |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 3:15pm ET |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 4 3:15pm ET |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 9:12am ET |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 9:12am ET |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 9:12am ET |
| Started | WR | Josh Downs IND | Owner | Tue Nov 4 9:12am ET |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 5:57pm ET |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 4 5:57pm ET |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 4 5:57pm ET |
| Benched | TE | Noah Fant CIN | Owner | Tue Nov 4 5:57pm ET |
| Started | QB | Drake Maye NE | Owner | Tue Nov 4 5:57pm ET |
| Started | RB | Brian Robinson Jr. SF | Owner | Tue Nov 4 5:57pm ET |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 5:57pm ET |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 4 5:57pm ET |
| Benched | QB | Kyler Murray ARI | Owner | Tue Nov 4 11:17pm ET |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Nov 4 11:17pm ET |
| Benched | QB | J.J. McCarthy MIN | Owner | Tue Nov 4 11:11am ET |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 11:11am ET |
| Benched | K | Chris Boswell PIT | Owner | Tue Nov 4 11:11am ET |
| Started | QB | Kyler Murray ARI | Owner | Tue Nov 4 11:11am ET |
| Started | WR | Kendrick Bourne SF | Owner | Tue Nov 4 11:11am ET |
| Started | K | Ka'imi Fairbairn HOU | Owner | Tue Nov 4 11:11am ET |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 4 7:46pm ET |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 7:46pm ET |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 7:46pm ET |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 4 7:46pm ET |
| No starting lineup changes performed this week. |