

| Benched | WR | Jauan Jennings SF | Owner | Thu Nov 27 7:28pm CT |
| Started | WR | Mason Tipton NO | Owner | Thu Nov 27 7:28pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Jaylen Warren PIT | Owner | Thu Nov 27 11:18am CT |
| Started | RB | RJ Harvey DEN | Owner | Thu Nov 27 11:18am CT |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 25 7:52am CT |
| Benched | RB | D'Andre Swift CHI | Owner | Tue Nov 25 7:52am CT |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 25 7:52am CT |
| Started | WR | Jaylen Waddle MIA | Owner | Tue Nov 25 7:52am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 25 10:58am CT |
| Started | WR | Chimere Dike TEN | Owner | Tue Nov 25 10:58am CT |
| No starting lineup changes performed this week. |
| Benched | TE | Chigoziem Okonkwo TEN | Owner | Thu Nov 27 11:54am CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Thu Nov 27 11:54am CT |
| Benched | QB | Baker Mayfield TB | Owner | Thu Nov 27 5:02pm CT |
| Started | QB | Joe Burrow CIN | Owner | Thu Nov 27 5:02pm CT |
| Benched | RB | Emanuel Wilson GB | Owner | Wed Nov 26 7:06am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Wed Nov 26 7:06am CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Nov 26 9:30pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Wed Nov 26 9:30pm CT |
| Benched | K | Michael Badgley IND | Owner | Wed Nov 26 9:30pm CT |
| Started | RB | Josh Jacobs GB | Owner | Wed Nov 26 9:30pm CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 26 9:30pm CT |
| Started | K | Cameron Dicker LAC | Owner | Wed Nov 26 9:30pm CT |
| Benched | RB | Isaiah Davis NYJ | Owner | Wed Nov 26 7:04pm CT |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Nov 26 7:04pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Nov 26 7:04pm CT |
| Started | WR | Malik Washington MIA | Owner | Wed Nov 26 7:04pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Drake Maye NE | Owner | Tue Nov 25 11:07am CT |
| Started | QB | Patrick Mahomes KC | Owner | Tue Nov 25 11:07am CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 25 11:06am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 25 11:06am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 25 10:05pm CT |
| Benched | RB | Rhamondre Stevenson NE | Owner | Tue Nov 25 10:05pm CT |
| Started | QB | Tyler Shough NO | Owner | Tue Nov 25 10:05pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 25 10:05pm CT |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 25 2:44pm CT |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 25 2:44pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 25 2:44pm CT |
| Started | D/ST | Houston Texans HOU | Owner | Tue Nov 25 2:44pm CT |
| Benched | RB | Nick Chubb HOU | Owner | Thu Nov 27 9:57am CT |
| Benched | K | Daniel Carlson LV | Owner | Thu Nov 27 9:57am CT |
| Started | RB | Bucky Irving TB | Owner | Thu Nov 27 9:57am CT |
| Started | K | Andre Szmyt CLE | Owner | Thu Nov 27 9:57am CT |
| Benched | RB | Kyle Juszczyk SF | Owner | Thu Nov 27 7:02am CT |
| Benched | TE | Pat Freiermuth PIT | Owner | Thu Nov 27 7:02am CT |
| Started | RB | Devon Achane MIA | Owner | Thu Nov 27 7:02am CT |
| Started | WR | Ladd McConkey LAC | Owner | Thu Nov 27 7:02am CT |