

| Started | K | Andres Borregales NE | Owner | Thu Nov 20 1:58pm ET |
| Benched | RB | Devon Achane MIA | Owner | Thu Nov 20 1:50pm ET |
| Benched | WR | Drake London ATL | Owner | Thu Nov 20 1:50pm ET |
| Benched | TE | Oronde Gadsden II LAC | Owner | Thu Nov 20 1:50pm ET |
| Started | RB | Emanuel Wilson GB | Owner | Thu Nov 20 1:50pm ET |
| Started | WR | Jakobi Meyers JAX | Owner | Thu Nov 20 1:50pm ET |
| Started | WR | Brian Thomas Jr. JAX | Owner | Thu Nov 20 1:50pm ET |
| No starting lineup changes performed this week. |
| Started | QB | Sam Darnold SEA | Owner | Thu Nov 20 12:19pm ET |
| Benched | QB | Justin Herbert LAC | Owner | Wed Nov 19 10:49pm ET |
| Benched | WR | Courtland Sutton DEN | Owner | Wed Nov 19 10:49pm ET |
| Benched | TE | Jonnu Smith PIT | Owner | Wed Nov 19 10:49pm ET |
| Started | RB | Zach Charbonnet SEA | Owner | Wed Nov 19 10:49pm ET |
| Started | TE | Tyler Warren IND | Owner | Wed Nov 19 10:49pm ET |
| No starting lineup changes performed this week. |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 20 8:49am ET |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 18 6:07pm ET |
| Benched | RB | Chuba Hubbard CAR | Owner | Tue Nov 18 6:07pm ET |
| Started | K | Will Reichard MIN | Owner | Tue Nov 18 6:05pm ET |
| Started | WR | Chris Olave NO | Owner | Tue Nov 18 6:05pm ET |
| Started | RB | Chuba Hubbard CAR | Owner | Tue Nov 18 6:05pm ET |
| Benched | D/ST | Denver Broncos DEN | Owner | Tue Nov 18 6:05pm ET |
| Benched | K | Cameron Dicker LAC | Owner | Tue Nov 18 6:05pm ET |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 18 6:05pm ET |
| Benched | RB | Emari Demercado ARI | Owner | Tue Nov 18 6:05pm ET |
| No starting lineup changes performed this week. |
| Started | K | Ka'imi Fairbairn HOU | Owner | Thu Nov 20 3:17pm ET |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 20 6:32am ET |
| Benched | WR | Zay Flowers BAL | Owner | Wed Nov 19 9:55pm ET |
| Started | RB | Woody Marks HOU | Owner | Wed Nov 19 9:55pm ET |
| Benched | WR | Jauan Jennings SF | Owner | Wed Nov 19 5:20pm ET |
| Started | WR | Jameson Williams DET | Owner | Wed Nov 19 5:20pm ET |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 18 8:29am ET |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 18 8:29am ET |
| No starting lineup changes performed this week. |
| Benched | QB | Aaron Rodgers PIT | Owner | Tue Nov 18 10:36am ET |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 18 10:36am ET |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 10:36am ET |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 18 10:36am ET |
| Started | RB | Kareem Hunt KC | Owner | Tue Nov 18 10:36am ET |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Nov 18 10:36am ET |
| No starting lineup changes performed this week. |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Wed Nov 19 9:24am ET |
| Started | WR | Michael Pittman Jr. IND | Owner | Wed Nov 19 9:24am ET |
| Benched | RB | RJ Harvey DEN | Owner | Thu Nov 20 6:57am ET |
| Started | WR | Tre Tucker LV | Owner | Thu Nov 20 6:57am ET |
| Benched | TE | Colston Loveland CHI | Owner | Thu Nov 20 6:57am ET |
| Started | TE | Juwan Johnson NO | Owner | Thu Nov 20 6:57am ET |
| Benched | RB | Rachaad White TB | Owner | Thu Nov 20 6:57am ET |
| Started | RB | Jonathan Taylor IND | Owner | Thu Nov 20 6:57am ET |